The Immunohistochemistry Antibody Company
|Human, Rat (tested or 100% immunogen sequence identity)|
|Western blot (2 µg/ml)|
|WNK4 antibody was raised against a synthetic peptide sequence made to a region of the human protein between residues 200-300. Percent identity by BLAST analysis: Rat (100%).|
|Store at 4°C. Do not freeze.|
|For research use only.|
WNK4 Antibody, PHA2B Antibody, PRKWNK4 AntibodySerine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3.