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WFS1

Wolfram syndrome 1 (wolframin)

WFS1 is a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.

Gene Name: Wolfram syndrome 1 (wolframin)
Synonyms: WFS1, DIDMOAD, DFNA14, DFNA6, Wolframin, WFS, WFSL, Wolfram syndrome 1 (wolframin), DFNA38, WFRS, Wolfram Syndrome 1
Target Sequences: NM_006005 NP_005996.2 O76024

Publications (5)

1
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Takeda K, Inoue H, Tanizawa Y, Matsuzaki Y, Oba J, Watanabe Y, Shinoda K, Oka Y. Human molecular genetics. 2001 10:477-84. (ICC, IHC; Rat) [PubMed:11181571]
2
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y, Urano F. The Journal of biological chemistry. 2005 280:39609-15. (ICC, IHC, WB; Mouse, Primate) [PubMed:16195229]
3
Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. Xu R, Xia B, Geng J, Shi J, Shi H, Yuan L, De W. World journal of gastroenterology : WJG. 2009 15:5425-31. [PubMed:19916172] [PMC:PMC2778098]
4
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes. Helmut Hiller, Dawn E Beachy, Joseph J Lebowitz, Stefanie Engler, Justin R Mason, Douglas R Miller, Irina Kusmarteva, Laura M Jacobsen, Amanda L Posgai, Habibeh Khoshbouei, Richard A Oram, Desmond A Schatz, Andrew T Hattersley, Bernd Bodenmiller, Mark A Atkinson, Harry S Nick , Clive H Wasserfall. Diabetes. 2021 Aug;;70:1885-1897. [Full Text Article] [PubMed:34035041] [PMC:PMC8385619 (ava] Related Antibodies: LS-B14378.
5
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP C<sup>, in type 1 diabetes. Helmut Hiller, Changjun Yang, Dawn E Beachy, Irina Kusmartseva, Eduardo Candelario-Jalil, Amanda L Posgai, Harry S Nick , Desmond Schatz, Mark A Atkinson , Clive H Wasserfall. Diabetologia. 2021 Oct;;64:2279-2291. [Full Text Article] [PubMed:34274990] [PMC:PMC8715394] Related Antibodies: LS-B14378.
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☰ Filters
Antibodies (11)
ELISA Kits (6)
Proteins (6)
Over-Expression Lysate (4)
Primary (11)
Recombinant (2)
Sandwich (3)
Sandwich CLIA (3)
WFS1 (23)
Human (12)
Mouse (11)
Rat (9)
Monkey (1)
IHC (6)
IHC-P (3)
WB (10)
ELISA (2)
IP (1)
Peptide-ELISA (2)
rabbit (11)
Product Group
IHCPlus (2)
IgG (6)
polyclonal pc (11)
96-Well Strip Plate (6)
Unconjugated (11)
N-Terminus (1)
aa100-200 (1)
aa183-232 (1)
No (22)
Yes (1)
Tissue Homogenates (6)
Myc-DDK (Flag) (6)
Human (4)
293T Cells (2)
HEK 293 Cells (4)
WFS1 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
WFS1 Antibody - Anti-WFS1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
WFS1 Rabbit anti-Human Polyclonal (aa183-232) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
WFS1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$902
WFS1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$965
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
WFS1 Antibody - Western blot analysis of WFS1 expression in HeLa (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
Select
WFS1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µl/$299
Select
WFS1 Rabbit anti-Mouse Polyclonal (aa100-200) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
WFS1 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
WFS1 Antibody - Western blot of extracts of mouse brain cell lines, using WFS1 antibody.
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
WFS1 Antibody - Western blot of WFS1 antibody at 1:500 dilution Line1:HeLa whole cell lysate Line2:H9C2 whole cell lysate Line3:Raw264.7 whole cell lysate.
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
WFS1 Antibody - Immunochemical staining of human WFS1 in human placenta with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Select
WFS1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
WFS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
100.1 kDa
20 µg/$150
WFS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
100.1 kDa
20 µg/$215
WFS1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$968
WFS1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$990
WFS1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$1,034
WFS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
100.1 kDa
100 µg/$710
WFS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
100.1 kDa
100 µg/$494
WFS1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$923
WFS1 Protein - Purified recombinant protein WFS1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
100.1 kDa
20 µg/$1,107
WFS1 Protein - Purified recombinant protein WFS1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
100.1 kDa
20 µg/$1,107
Viewing 1-23 of 23 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).