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Anti-VWF / Von Willebrand Factor Antibody (clone RFF-VIII R/1) LS-C188527

Ordering

Wt. Vol. Conc. Price
200 µg - 1 mg/ml $355
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Most Popular VWF / Von Willebrand Factor Antibodies

Anti-VWF / Von Willebrand Factor Antibody (N-Terminus, clone VW92-3) LS-C83336
Mouse Monoclonal [clone VW92-3] (IgG2a) to Human VWF / Von Willebrand Factor
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
Anti-VWF / Von Willebrand Factor Antibody IHC-plus™ LS-B2590
Goat Polyclonal (IgG) to Human VWF / Von Willebrand Factor
Human
IHC - Paraffin, ELISA, Immunoelectrophoresis
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone RFF-VIII R/1] (IgG1) to Human VWF / Von Willebrand Factor
Human
IHC - Paraffin, ELISA, Radioimmunoassay
Unconjugated

Details

Human VWF / Von Willebrand Factor
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [RFF-VIII R/1]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (1:50 - 1:200)
  • ELISA
  • Radioimmunoassay

  • Western blot

Specificity and Use

VWF / Von Willebrand Factor antibody was raised against human Factor VIII complex partially purified from Factor VIII concentrate.
Recognizes human von Willebrand factor (vWF), also known as Factor VIII related antigen, a blood glycoprotein involved in blood coagulation. It stabilizes circulating Factor VIII by binding to it and protecting it from cleavage and delivers it to sites of vascular injury. vWF also promotes the adhesion of platelets to sites of vascular damage by forming a molecular bridge between collagen on exposed endothelial cells and the GPIb binding sites of platelets circulating in the blood. vWF circulates in the blood as large multimers, with each monomer (250kD) containing a number of specific domains. Hereditary or acquired defects in vWF lead to von Willebrand disease (vWD), characterized by varying degrees of susceptibility to bleeding. Symptoms might include nosebleeds, bleeding gums, easy bruising, menorrhagia or gastrointestinal bleeding. Various forms of vWD exist with differing severities, determined by the type of defect. Clone RF-VIII R/1 has a high affinity for an epitope within the platelet GPIb-binding site that is responsible for biological activity. As such the antibody is a potent inhibitor of vWF activity. It can completely neutralize ristocetin-induced platelet aggregation and ristocetin-induced binding of vWF to platelets. It also inhibits platelet adhesion to glass beads. The epitope recognized is present only on the intact multimeric form of vWF and is abolished by mild denaturation with SDS. The antibody does not recognize human Factor VIII. Clone RF-VIII R/1 may be used as a capture antibody in immunoassays for vWF in combination with clone RFF-VIII R/2 as a detection reagent.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About VWF / Von Willebrand Factor

P04275 NM_000552 NP_000543.2

VWF Antibody, Coagulation factor VIII VWF Antibody, F8VWF Antibody, VWD Antibody, Von Willebrand factor Antibody

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Requested From: United States
Date Requested: 12/8/2016

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