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Anti-VISA / MAVS Antibody LS-C187776

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $325
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular VISA / MAVS Antibodies

Anti-VISA / MAVS Antibody (N-Terminus) IHC-plus™ LS-B617
Rabbit Polyclonal to Human VISA / MAVS
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-VISA / MAVS Antibody (Internal) IHC-plus™ LS-B1435
Rabbit Polyclonal to Human VISA / MAVS
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-VISA / MAVS Antibody (aa150-200) LS-C287639
Rabbit Polyclonal (IgG) to Human VISA / MAVS
Human
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human VISA / MAVS
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated

Details

Human VISA / MAVS
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (0.5 - 1 µg/ml)

Specificity and Use

VISA / MAVS antibody was raised against a peptide corresponding to a 17 amino acid sequence from near the centre of Human VISA.
Recognizes the human Mitochondrial antiviral-signaling protein (MAVS), also known as Virus-induced-signalling-adaptor (VISA), and KIAA1271, VISA is a 540 amino acid outer mitochondrial membrane protein containing a single. VISA is an important protein required for innate immune defense against viruses. VISA acts downstream of which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothesized that VISA is involved in the regulation of apoptosis following viral infection. VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, monocytes and epithelial cells, with highest levels in tissues of the heart, skeletal muscle, liver, placenta and in peripheral blood leukocytes. Multiple isoforms of VISA generated by alternative splicing have been identified. Is reactive with full length VISA isoform 1. It does not react with isoforms 2,3,5 or 6, reactivity with isoform 4 is unknown.

Packaging

PBS, 0.02% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About VISA / MAVS

Q7Z434 NM_020746 NP_065797.2

MAVS Antibody, CARDIF Antibody, CARD adaptor inducing IFN-beta Antibody, IPS-1 Antibody, KIAA1271 Antibody, IFN-B promoter stimulator 1 Antibody, VISA Antibody, IPS1 Antibody

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state.

Immunohistochemistry

Immunohistochemistry
Immunohistochemistry of mouse brain with Rabbit anti-Human VISA

Western blot

Western blot
Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml

Requested From: United States
Date Requested: 12/2/2016

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