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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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VISA / MAVS Antibody LS‑C187776
MAVS antibody LS-C187776 is an unconjugated rabbit polyclonal antibody to MAVS (VISA) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C187776-100
100 µg (1 mg/ml)
Unavailable

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Antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA

Product Description

MAVS antibody LS-C187776 is an unconjugated rabbit polyclonal antibody to MAVS (VISA) from human, mouse and rat. Validated for IHC and WB.
About VISA / MAVS
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Q7Z434 NM_020746 NP_065797.2

MAVS Antibody, CARDIF Antibody, CARD adaptor inducing IFN-beta Antibody, IPS-1 Antibody, KIAA1271 Antibody, IFN-B promoter stimulator 1 Antibody, VISA Antibody, IPS1 Antibody


Specifications

Target
Human VISA / MAVS
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
VISA / MAVS antibody was raised against a peptide corresponding to a 17 amino acid sequence from near the centre of Human VISA.
Specificity
Recognizes the human Mitochondrial antiviral-signaling protein (MAVS), also known as Virus-induced-signalling-adaptor (VISA), and KIAA1271, VISA is a 540 amino acid outer mitochondrial membrane protein containing a single. VISA is an important protein required for innate immune defense against viruses. VISA acts downstream of which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothesized that VISA is involved in the regulation of apoptosis following viral infection. VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, monocytes and epithelial cells, with highest levels in tissues of the heart, skeletal muscle, liver, placenta and in peripheral blood leukocytes. Multiple isoforms of VISA generated by alternative splicing have been identified. Is reactive with full length VISA isoform 1. It does not react with isoforms 2,3,5 or 6, reactivity with isoform 4 is unknown.
Presentation
PBS, 0.02% sodium azide
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Immunohistochemistry of mouse brain with Rabbit anti-Human VISA
Immunohistochemistry of mouse brain with Rabbit anti-Human VISA

Western blot

Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml
Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml

Immunohistochemistry

Immunohistochemistry of mouse brain with Rabbit anti-Human VISA
Immunohistochemistry of mouse brain with Rabbit anti-Human VISA

Western blot

Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml
Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml

Immunohistochemistry

Immunohistochemistry of mouse brain with Rabbit anti-Human VISA
Immunohistochemistry of mouse brain with Rabbit anti-Human VISA

Western blot

Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml
Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml

Immunohistochemistry

Immunohistochemistry of mouse brain with Rabbit anti-Human VISA
Immunohistochemistry of mouse brain with Rabbit anti-Human VISA

Western blot

Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml
Western blot of rat brain lysate probed with Rabbit anti-Human VISA at 0.5(A), 1(B) and 2(C) ug/ml


Requested From: 
Date Requested: 6/21/2018

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