Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Protein G purified
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
VCAM1 / CD106 antibody was raised against cD 106.
Recognizes murine VCAM-1 single chain glycoprotein (Mr 100-kD) (under reducing conditions). VCAM- 1 is present on the +/+ 2.4 stromal cell clone, large cells in bone marrow and a subset of thymic macrophages. The stromal cell antigen is also detectable on the EOMA and BMS2 endothelial cell lines. Recognizes all known isoforms of mouse VCAM-1.
Suitable for use in Immunoprecipitation (VCAM-1 integrin complex), Immunofluorescence and Immunohistochemistry. May be used for the following: studies of cell-cell interaction, cell adhesion assays, and inhibition of lymphopoiesis in Whitlock-Witte long-term marrow cultures.
PBS, 10 mM Sodium Azide
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Vascular cell adhesion molecule 1, VCAM-1, is a surface glycoprotein expressed by cytokine-activated endothelium that mediates the adhesion of monocytes and lymphocytes. VCAM-1 and integrin alpha-4-beta-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization. Studies of heart development have shown that deficiencies of VCAM and in alpha-4 integrin also result in epicardial dissolution and subsequent myocardial thinning.