Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [M/K-2]
Specificity and Use
Recognizes CD106/VCAM-1 (~Mr 100kD).
Identification and enumeration of CD106 cells by flow cytometry. Identification of VCAM-1+ cells by immunofluorescence and immunohistochemical staining. Blockage of lymphocyte adhesion in Whitlock-Witte long-term bone marrow cultures. Inhibition of lymphopoiesis in Whitlock-Witte cultures. Immunoprecipitation. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
PBS. No preservatives added.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
Vascular cell adhesion molecule 1, VCAM-1, is a surface glycoprotein expressed by cytokine-activated endothelium that mediates the adhesion of monocytes and lymphocytes. VCAM-1 and integrin alpha-4-beta-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization. Studies of heart development have shown that deficiencies of VCAM and in alpha-4 integrin also result in epicardial dissolution and subsequent myocardial thinning.