Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1 - 3 µg/ml), Immunoprecipitation (1 - 5 µg/ml), ELISA (0.1 - 1 µg/ml)
Specificity and Use
VAV2 antibody was raised against synthetic peptide derived from the C-terminal region of the human Vav2 protein.
Specific for the human Vav2 protein. On Western blots, it identifies a single band at ~100kD. Reactivity has been confirmed with human T47D breast carcinoma, SK-OV3 ovarian carcinoma and U-937 lymphoma cell lysates.
Suitable for use in ELISA, Western Blot, Immunoprecipitation. ELISA: 0.1-1 ug/ml. Western Blot: 1-3 ug/ml. Immunoprecipitation: 1-5 ug/ml.
PBS, pH 7.2, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.