USP28

ubiquitin specific peptidase 28

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.

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Products

Antibodies (24)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (24)

Recombinant (4)

Target

USP28 (30)

Reactivity

Human (24)

Mouse (2)

Rat (1)

Bovine (1)

Dog (1)

Horse (1)

Monkey (1)

Pig (1)

Rabbit (1)

Application

IHC (13)

IHC-P (3)

WB (14)

ELISA (16)

IP (3)

Peptide-ELISA (2)

Host

rabbit (23)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (19)

Clonality

polyclonal pc (24)

Format

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (14)

Epitope

aa111-141 (7)

C-Terminus (6)

aa50-100 (2)

aa500-550 (1)

aa674-685 (1)

Publications

No (30)

Tag

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

USP28 Antibody (aa111-141) LS-C99574

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ USP28 Antibody (aa674-685) LS-B6475

(4.0) Rating

Antibody:

USP28 Goat anti-Human Polyclonal (aa674-685) Antibody

Reactivity:

Rabbit, Dog, Bovine, Pig, Horse, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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USP28 Antibody LS-C676695

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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USP28 Antibody LS-C661493

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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USP28 Antibody LS-C676694

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

USP28 Antibody (aa50-100) LS-C287737

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

USP28 Antibody (C-Terminus) LS-C329073

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

Select

USP28 Antibody (C-Terminus, Biotin) LS-C226674

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (C-Terminus, FITC) LS-C226676

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (C-Terminus, APC) LS-C226673

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (C-Terminus, Azide-free, HRP) LS-C226677

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

USP28 Antibody (C-Terminus, PE) LS-C226680

Antibody:

USP28 Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

USP28 Antibody (aa500-550) LS-C286030

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa500-550) Antibody

Reactivity:

Human

Applications:

IHC, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

USP28 Antibody (aa111-141) LS-C329074

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

USP28 Antibody (aa111-141, Biotin) LS-C226669

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (aa111-141, FITC) LS-C226670

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (aa111-141, APC) LS-C226668

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

USP28 Antibody (aa111-141, Azide-free, HRP) LS-C226671

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

USP28 Antibody (aa111-141, PE) LS-C226672

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa111-141) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

USP28 Antibody LS-C778991

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

USP28 Antibody LS-C809131

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

USP28 Antibody (aa50-100) LS-C286436

Antibody:

USP28 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

0.5 µg/$295; 100 µl/$532

Select

USP28 Antibody LS-C668590

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

USP28 Antibody LS-C760934

Antibody:

USP28 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

USP28 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.3 kDa

Price:

100 µg/$710

Viewing 1-25 of 30 product results

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