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USP2

ubiquitin specific peptidase 2

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.

Gene Name: ubiquitin specific peptidase 2
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP2, Deubiquitinating enzyme 2, Ubiquitin specific peptidase 2, Ubiquitin specific protease 9, USP9, Ubiquitin specific protease 12, Ubiquitin specific protease 2, Ubiquitin thioesterase 2, UBP41
Target Sequences: NM_004205 NP_004196.4 O75604

Publications (2)

1
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The EMBO journal. 2007 26:976-86. [PubMed:17290220] [PMC:PMC1852834] Related Antibodies: LS-C99527.
2
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2. Oberfeld B, Ruffieux-Daidi D, Vitagliano JJ, Pos KM, Verrey F, Staub O. American journal of physiology. Renal physiology. 2011 301:F189-96. [PubMed:21478478] Related Antibodies: LS-C99529.

☰ Filters
Antibodies (45)
Proteins (7)
Over-Expression Lysate (4)
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USP2 (52)
Human (42)
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rabbit (44)
mouse (1)
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IgG (27)
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monoclonal mc (1)
polyclonal pc (44)
1738CT331.50.87 (1)
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Azide-free (3)
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aa380-410 (7)
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293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
USP2 Antibody - Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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USP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
USP2 Antibody - Anti-USP2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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USP2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
USP2 Antibody - IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. Cytoplasmic positive immunostaining was detected in tumor glands (ii), whereas in normal prostatic epithelium, USP2a expression was restricted to the basal layer.
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USP2 Rabbit anti-Human Polyclonal (aa71-101) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
USP2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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USP2 Rabbit anti-Human Polyclonal (aa508-538) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
USP2 Antibody - Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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USP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
USP2 Antibody - Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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USP2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
USP2 Antibody - The anti-USP2 Antibody is used in Western blot to detect USP2 in USP2-transfected HeLa cell lysates. Transfection data is kindly provided by Dr. B. Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland).
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USP2 Rabbit anti-Human Polyclonal (aa380-410) Antibody
Human
WB
Unconjugated
400 µl/$393
USP2 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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USP2 Rabbit anti-Human Polyclonal (aa371-420) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
USP2 Protein - Recombinant Ubiquitin Specific Peptidase 2 (USP2) by SDS-PAGE
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E. coli
His, N-Terminal
26.1kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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USP2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$1,056
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USP2 Rabbit anti-Human Polyclonal (aa508-538) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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USP2 Rabbit anti-Human Polyclonal (aa508-538) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa508-538) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa508-538) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa508-538) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa508-538) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
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USP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
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USP2 Rabbit anti-Human Polyclonal (aa71-101) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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USP2 Rabbit anti-Human Polyclonal (aa71-101) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa71-101) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa71-101) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa71-101) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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USP2 Rabbit anti-Human Polyclonal (aa71-101) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
USP2 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
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USP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Viewing 1-25 of 52 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).