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Anti-USP2 Antibody (aa71-101) LS-C99527

Ordering

Wt. Vol. Conc. Price
- 400 µl - $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular USP2 Antibodies

Anti-USP2 Antibody (Internal) IHC-plus™ LS-A8743
Rabbit Polyclonal to Human USP2
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-USP2 Antibody (Internal) IHC-plus™ LS-A8495
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-USP2 Antibody (C-Terminus) IHC-plus™ LS-A8493
Rabbit Polyclonal to Human USP2
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Rabbit
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal to Human USP2
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human USP2
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

  • IHC - Paraffin (1:10 - 1:50)
  • Western blot (1:1000)

Specificity and Use

USP2 antibody was raised against kLH-conjugated synthetic peptide between amino acids 71-101 from N-terminal region of human USP2.
LS-E6875 - Lyophilized - 100 µg - $145.00
aa71-101

Packaging

PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
For research use only.

Publications (1)

1
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The EMBO journal. 2007 26:976-86. [PubMed:17290220] [PMC:PMC1852834]

About USP2

O75604 NM_004205 NP_004196.4

USP2 Antibody, Deubiquitinating enzyme 2 Antibody, Ubiquitin specific peptidase 2 Antibody, Ubiquitin specific protease 9 Antibody, USP9 Antibody, Ubiquitin specific protease 12 Antibody, Ubiquitin specific protease 2 Antibody, Ubiquitin thioesterase 2 Antibody, UBP41 Antibody

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4.

Immunohistochemistry

Immunohistochemistry
IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. Cytoplasmic positive immunostaining was detected in tumor glands (ii), whereas in normal prostatic epithelium, USP2a expression was restricted to the basal layer.

Western blot

Western blot
Western blot of USP2 (arrow) using rabbit polyclonal USP2 Antibody (T22). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the USP2 gene.

Western blot

Western blot
Western blot of lysate from R. heart cell line, using USP2 Antibody (T22). Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

Western blot

Western blot
Western blot of USP2 Antibody in HL60 cell line lysates (35 ug/lane). USP2 (arrow) was detected using the purified antibody.

Requested From: United States
Date Requested: 12/7/2016

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