Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The EMBO journal. 2007 26:976-86.
USP2 Antibody, Deubiquitinating enzyme 2 Antibody, Ubiquitin specific peptidase 2 Antibody, Ubiquitin specific protease 9 Antibody, USP9 Antibody, Ubiquitin specific protease 12 Antibody, Ubiquitin specific protease 2 Antibody, Ubiquitin thioesterase 2 Antibody, UBP41 Antibody
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4.
IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. Cytoplasmic positive immunostaining was detected in tumor glands (ii), whereas in normal prostatic epithelium, USP2a expression was restricted to the basal layer.
Western blot of USP2 (arrow) using rabbit polyclonal USP2 Antibody (T22). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the USP2 gene.
Western blot of lysate from R. heart cell line, using USP2 Antibody (T22). Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Western blot of USP2 Antibody in HL60 cell line lysates (35 ug/lane). USP2 (arrow) was detected using the purified antibody.