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UNC84B / SUN2
Sad1 and UNC84 domain containing 2
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
| Gene Name: | Sad1 and UNC84 domain containing 2 |
| Synonyms: | SUN2, FRIGG, Nuclear envelope protein, Protein unc-84 homolog B, Sad1 unc-84 domain protein 2, Sad1/unc-84 protein-like 2, Unc-84 homolog B, Unc-84 homolog B (C. elegans), KIAA0668, Rab5-interacting protein, RAB5IP, UNC84B |
| Target Sequences: | NM_015374 NP_056189.1 Q9UH99 |
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