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UMOD / Uromodulin
uromodulin
UMOD / Uromodulin is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
| Gene Name: | uromodulin |
| Synonyms: | UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin |
| Target Sequences: | NM_003361 NP_003352.2 P07911 |
Publications (5)
1
Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC. Biology of sex differences. 2015 6:2. (Flo; Human)
[Full Text Article]
[PubMed:25729563]
[PMC:PMC4345020]
Related Antibodies: LS-B3105.
2
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M. Journal of Extracellular Vesicles. 2016 5:29642. (Flo; Human)
[PubMed:26837814]
[PMC:PMC4737715]
Related Antibodies: LS-B3105.
3
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Saarela U, Akram SU, Desgrange A, Rak-Raszewska A, Shan J, Cereghini S, Ronkainen VP, Heikkilä J, Skovorodkin I, Vainio SJ. Development (Cambridge, England). 2017 144:1113-1117. (IHC; Mouse)
[Full Text Article]
[PubMed:28219945]
[PMC:PMC5358112]
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UMOD / Uromodulin Mouse anti-Human Monoclonal (FITC) (10.32) Antibody
Dog, Human
ELISA, IF, IHC, IHC-Fr, IHC-P
FITC Conjugated
50 µg/$460
Cancer
UMOD / Uromodulin Mouse anti-Human Monoclonal (10.32) Antibody
Dog, Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa352-380) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
UMOD / Uromodulin Mouse anti-Human Monoclonal (10.32) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
1 ml/$503
UMOD / Uromodulin Rabbit anti-Rat Polyclonal (aa30-150) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
Yeast
6His, N-terminus
64.22 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$854
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$893
UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa503-552) Antibody
Human
WB
Unconjugated
100 µl/$424
UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa503-552) (Biotin) Antibody
Dog, Guinea pig, Bovine, Horse, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal (Val378) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
E. coli
His,N-terminus
29.8 kDa
10 µg/$283; 50 µg/$452; 200 µg/$905; 1 mg/$2,020; 5 mg/$3,165; 2 mg/$2,209
UMOD / Uromodulin Mouse anti-Human Monoclonal (HRP) (10.32) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
HRP Conjugated
100 µg/$466
UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa352-380) (Azide-free) (HRP) Antibody
Human
IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
UMOD / Uromodulin Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
0.1 mg/$485
E. coli
His-GST
60.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
UMOD / Uromodulin Sheep anti-Mouse Polyclonal (aa24-618) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$930
UMOD / Uromodulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
60 µl/$460
293T Cells
Myc-DDK (Flag)
69.76 kDa
20 µg/$215
E. coli
His-T7
16.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$757; 200 µg/$945; 1 mg/$2,073; 500 µg/$1,604; 5 mg/$3,305; 2 mg/$2,262
Sandwich
96-Well Strip Plate
Dog
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$929
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