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Anti-ULK2 Antibody (aa370-382) LS-C187714

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $420
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular ULK2 Antibodies

Anti-ULK2 Antibody (phospho-Ser323, FITC) LS-C218334
Rabbit Polyclonal (IgG) to Human ULK2
Human
ELISA, Dot Blot
FITC Conjugated
Anti-ULK2 Antibody (C-Terminus) IHC-plus™ LS-B13288
Rabbit Polyclonal to Human ULK2
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Mouse ULK2
Mouse
Western blot
Unconjugated

Details

Mouse ULK2
Rabbit
Mouse (tested or 100% immunogen sequence identity)
Human, Rat (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

Western blot (2.5 - 5 µg/ml)

Specificity and Use

ULK2 antibody was raised against kLH conjugated synthetic peptide corresponding to amino acids 370-382 of mouse Ulk2. The corresponding sequence differs by two amino acids in rat and three amino acids in human.
aa370-382
Recognizes mouse Ulk2 (Serine/threonine-protein kinase Ulk2), otherwise known as Unc-51-like kinase 2, a widely expressed mammalian Atg1 homologue and member of the protein kinase superfamily, which shares structural similarity with a serine/threonine kinase found in C. elegans, known to be involved in axonal elongation. Studies have shown that murine Ulk2 and closely-related Ulk1, localize to autophagic isolation membranes under starvation conditions, and that the binding of Atg13 (Autophagy-related protein 13) to Ulk1 and Ulk2, stabilizes and activates them, and facilitates the phosphorylation of FIP200, a multifunctional protein involved in cell migration, proliferation, apoptosis, and tumor suppression.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About ULK2

Q8IYT8 NM_014683 NP_055498.3

ULK2 Antibody, ATG1B Antibody, KIAA0623 Antibody, Unc-51-like kinase 2 Antibody, Unc51.2 Antibody

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR.

Requested From: United States
Date Requested: 12/7/2016

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