UHRF1

ubiquitin-like with PHD and ring finger domains 1

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.

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Products

Antibodies (37)

Proteins (6)

ELISA Kits (1)

Type

Over-Expression Lysate (4)

Primary (37)

Recombinant (2)

Sandwich (1)

Target

UHRF1 (44)

Reactivity

Human (35)

Mouse (10)

Rat (5)

Bovine (3)

Chimpanzee (6)

Dog (4)

Gibbon (3)

Guinea pig (4)

Monkey (3)

Orangutan (3)

Zebrafish (3)

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Application

IHC (11)

IHC-P (5)

WB (36)

Flo (2)

ChrIP (1)

ELISA (11)

ICC (2)

IF (8)

IP (2)

Peptide-ELISA (4)

Host

rabbit (27)

mouse (7)

goat (1)

rabbit-new zealand white (1)

rat (1)

Product Group

IHCPlus (1)

Isotype

IgG (14)

IgG1 (1)

IgG1,k (1)

IgG2a,k (1)

IgG2b (2)

Clonality

monoclonal mc (8)

polyclonal pc (29)

Clone

1A1B1 (1)

2A8C7 (1)

3A11 (1)

Th-10a (1)

Format

96-Well Strip Plate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (26)

Epitope

aa229-257 (7)

N-Terminus (5)

aa584-633 (4)

Internal (2)

aa275-325 (2)

aa14-51 (1)

aa592-626 (1)

aa596-628 (1)

aa795-806 (1)

Publications

No (44)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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UHRF1 Antibody (clone Th-10a) LS-C179534

Antibody:

UHRF1 Rat anti-Mouse Monoclonal (Th-10a) Antibody

Reactivity:

Mouse

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$464

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UHRF1 Antibody LS-C806412

Antibody:

UHRF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ChrIP, IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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UHRF1 Antibody (clone 3A11) LS-C105136

Antibody:

UHRF1 Mouse anti-Human Monoclonal (3A11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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UHRF1 Antibody (clone 1A1B1) LS-C669546

Antibody:

UHRF1 Mouse anti-Human Monoclonal (1A1B1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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UHRF1 Antibody LS-C490576

Antibody:

UHRF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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UHRF1 Antibody (N-Terminus) LS-C110343

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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UHRF1 Antibody (aa584-633) LS-B14002

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa584-633) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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UHRF1 Antibody LS-C332075

Antibody:

UHRF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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UHRF1 Antibody (aa275-325) LS-C288266

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa275-325) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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UHRF1 Antibody (aa229-257) LS-C160423

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa229-257) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human UHRF1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71450

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.9 kDa

Price:

20 µg/$1,107

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UHRF1 Antibody (N-Terminus) LS-C178308

Antibody:

UHRF1 Mouse anti-Human Monoclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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UHRF1 Antibody LS-C771618

Antibody:

UHRF1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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UHRF1 Antibody (aa14-51) LS-C408117

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa14-51) Antibody

Reactivity:

Dog, Guinea pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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UHRF1 Antibody (clone 2A8C7) LS-C669545

Antibody:

UHRF1 Mouse anti-Human Monoclonal (2A8C7) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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UHRF1 Antibody LS-C813147

Antibody:

UHRF1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$406; 200 µg/$505

Select

UHRF1 Antibody LS-C829625

Antibody:

UHRF1 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

Select

UHRF1 Antibody LS-C813150

Antibody:

UHRF1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

UHRF1 Antibody (aa229-257) LS-C329018

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa229-257) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

UHRF1 Antibody (aa229-257, Biotin) LS-C246479

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa229-257) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

UHRF1 Antibody (aa229-257, Azide-free, HRP) LS-C247957

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa229-257) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• HRP, Azide-free

• Unconjugated
• Biotin
• HRP, Azide-free

Select

UHRF1 Antibody (Internal) LS-C386833

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

UHRF1 Antibody (aa275-325) LS-C286768

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa275-325) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

UHRF1 Antibody (aa596-628) LS-C356487

Antibody:

UHRF1 Rabbit anti-Mouse Polyclonal (aa596-628) Antibody

Reactivity:

Mouse

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

UHRF1 Antibody (aa592-626) LS-C356473

Antibody:

UHRF1 Rabbit anti-Human Polyclonal (aa592-626) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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