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UGT1A / UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A / UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Gene Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms: UGT1A1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1A, BILIQTL1, UGT1, UGT1*1, UGT1-01, UGT-1A, UGT1.1
Target Sequences: NM_000463 NP_000454.1 P22309

Publications (1)

1
Prenatal glucocorticoid administration enhances bilirubin metabolic capacity and increases Ugt1a and Abcc2 gene expression via glucocorticoid receptor and PXR in rat fetal liver. Tsukasa Kobayashi, Yuko Takeba, Yuki Ohta, Masanori Ootaki, Keisuke Kida, Minoru Watanabe, Taroh Iiri, Naoki Matsumoto. The journal of obstetrics and gynaecology research. 2022 July;48:1591-1606. [Full Text Article] [PubMed:35445507]

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UGT1A / UGT1A1 (42)
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UGT1A / UGT1A1 Antibody - UGT1A1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
UGT1A / UGT1A1 Protein
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Yeast
6His, N-terminus
59.1 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
UGT1A / UGT1A1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa65-90) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
UGT1A / UGT1A1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
UGT1A / UGT1A1 Antibody - Western blot analysis of extracts of various cell lines, using UGT1A1 antibody.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
UGT1A / UGT1A1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
UGT1A / UGT1A1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
UGT1A / UGT1A1 Antibody - Immunohistochemistry - Anti-UGT1A1 Picoband antibody
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
UGT1A / UGT1A1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
UGT1A / UGT1A1 Antibody - Immunofluorescence analysis of U2OS cells using UGT1A1 Polyclonal Antibody.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
UGT1A / UGT1A1 Antibody - UGT1A1 antibody ARP44294_T100-NP_000454-UGT1A1(UDP glucuronosyltransferase 1 family, polypeptide A1) Antibody Western blot of Fetal Liver lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$397
UGT1A / UGT1A1 Antibody - UGT1A1 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
WB
Unconjugated
100 µl/$424
UGT1A / UGT1A1 Antibody - UGT1A1 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa36-85) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$469
UGT1A / UGT1A1 Antibody - UGT1A1 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa36-85) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$469
UGT1A / UGT1A1 Antibody - UGT1A1 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal (aa36-85) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$469
UGT1A / UGT1A1 Antibody
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
UGT1A / UGT1A1 Antibody - Western blot analysis of UGT1A1 expression in HepG2 (A); SHSY5Y (B); mouse liver (C); rat liver (D) whole cell lysates.
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UGT1A / UGT1A1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
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UGT1A / UGT1A1 Goat anti-Human Polyclonal (aa60-168) Antibody
Human
WB
Unconjugated
100 µg/$941
Viewing 1-25 of 42 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).