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Anti-UCHL1 / PGP9.5 Antibody (clone 31A3) LS-C11453

Ordering

Wt. Vol. Conc. Price
200 µg - 1 mg/ml $405
Inquire for larger quantities

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Mouse Monoclonal [clone 31A3] (IgG1) to Human UCHL1 / PGP9.5
Human, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human UCHL1 / PGP9.5
Mouse
Human, Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [31A3]
Protein G purified

Applications

IHC - Paraffin (1:100 - 1:400), Western blot, ELISA (1:500 - 1:2000)

Specificity and Use

UCHL1 / PGP9.5 antibody was raised against native, from brain.
Recognizes protein gene product 9.5 (PGP9.5), a ubiquitin hydrolase which is widely expressed in neuronal tissues and represents 1-2% of total soluble brain proteins. PGP9.5, also known as ubiquitin C-terminal hydrolase 1 (UCHL-1), is involved in the regulation of the ubiquitin pathway. Stains neuronal cell bodies and axons in the CNS and periphery, small nerve fibres in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES. Clones 31A3 and each recognize a different epitope towards the N-terminus of the protein. Also recognizes PGP9.5 in other species, including rat and rabbit but evidence suggests it does not bind to PGP9.5 in guinea pigs. Has been used successfully as a capture reagent with clone 13C4 as a detection reagent in a sandwich ELISA to evaluate contamination of processed meat samples with neuronal tissue.

Packaging

PBS, pH 7.2, 0.09% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About UCHL1 / PGP9.5

P09936 NM_004181 NP_004172.2

UCHL1 Antibody, Ubiquitin C-terminal hydrolase Antibody, PARK5 Antibody, PGP9.5 Antibody, PGP95 Antibody, Ubiquitin thioesterase L1 Antibody, Neuron cytoplasmic protein 9.5 Antibody, PGP 9.5 Antibody, Uch-L1 Antibody

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Requested From: United States
Date Requested: 9/29/2016

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