Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 10A1] (IgG2b) to Human UCHL1 / PGP9.5
IHC - Paraffin, IHC - Frozen, Western blot
Human UCHL1 / PGP9.5
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [10A1]
Tissue culture supernatant
IHC - Paraffin
IHC - Frozen
Specificity and Use
UCHL1 / PGP9.5 antibody was raised against recombinant fusion protein corresponding to the full length of human PGP9.5.
Recognizes protein gene product 9.5 (PGP9.5), a ubiquitin hydrolase which is widely expressed in neuronal tissues. PGP9.5, also know as ubiquitin C-terminal hydrolase 1 (UCHL-1), has also been identified as a constituent of Lewy bodies.
Tissue culture supernatant, 0.09% sodium azide
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.