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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | ubiquitin-like modifier activating enzyme 3 |
Synonyms: | UBA3, HUBA3, UBE1C, Ubiquitin-activating enzyme 3, NEDD8-activating enzyme E1C, Nedd8-activating enzyme hUba3 |
Target Sequences: | NM_003968 NP_003959.3 Q8TBC4 |
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