Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG) to Human TXN / Thioredoxin / TRX
Goat Polyclonal (IgG) to Human TXN / Thioredoxin / TRX
Western blot, ELISA
Human TXN / Thioredoxin / TRX
Human (tested or 100% immunogen sequence identity)
Western blot (0.05 - 0.5 µg/ml)
ELISA (0.05 - 0.2 µg/ml)
Specificity and Use
Purified recombinant Trx-tag fusion protein.
Specific for the Thioredoxin fusion protein from human and E. coli. Reacts with the 109-aa Trx-tag sequence encoded by pET-32a expression vectors. Suitable for detecting fusion proteins that contain a Trx-tag.
Suitable for use in ELISA and Western Blot. ELISA: 0.05-0.2 ug/ml. Western Blot: 0.05-0.5 ug/ml.
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.