Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG) to Human TXN / Thioredoxin / TRX
Western blot, ELISA
Rabbit Polyclonal to Human TXN / Thioredoxin / TRX
Human TXN / Thioredoxin / TRX
Human (tested or 100% immunogen sequence identity)
Ammonium sulfate precipitation
Specificity and Use
Recognizes thioredoxin, a small ubiquitous protein found in both prokaryotic and eukaryotic organisms. E. coli. is a 109 amino acid protein. It is involved in a wide range of intracellular redox reactions. Thioredoxin is highly conserved particularly at the enzymatic active site and this is expected to cross react with thioredoxin from many species.
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.