Tuberin / TSC2

tuberous sclerosis 2

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.

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Antibodies (234)

ELISA Kits (4)

Proteins (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (234)

Recombinant (1)

Sandwich (2)

Target

Tuberin / TSC2 (241)

Reactivity

Human (167)

Mouse (124)

Rat (54)

Bat (1)

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Horse (2)

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rabbit (219)

mouse (15)

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monoclonal mc (15)

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1C1 (1)

249CT19.1.3 (7)

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No (239)

Yes (2)

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GST, N-terminus (1)

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Source

293T Cells (1)

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Wheat Germ Extract (1)

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IHC-plus™ Tuberin / TSC2 Antibody (phospho-Ser664) LS-B1654

(5.0) Rating

(2) Publication(s)

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer664) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ Tuberin / TSC2 Antibody (clone 249CT19.1.3) LS-B11230

(4.0) Rating

Antibody:

Tuberin / TSC2 Mouse anti-Mouse Monoclonal (249CT19.1.3) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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IHC-plus™ Tuberin / TSC2 Antibody (Ser1798) LS-B6311

(4.0) Rating

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (Ser1798) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$440

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IHC-plus™ Tuberin / TSC2 Antibody LS-B613

(4.0) Rating

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$440

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Tuberin / TSC2 Antibody (phospho-Ser939) LS-C358381

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer939) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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Tuberin / TSC2 Antibody (phospho-Ser1798) LS-C96812

(4.0) Rating

(1) Publication(s)

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer1798) Antibody

Reactivity:

Human

Applications:

DB, IF

Format:

Unconjugated

Price:

400 µl/$393

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Tuberin / TSC2 Antibody (1400-1480 aa) LS-C381573

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (1400-1480 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Tuberin / TSC2 Antibody (phospho-Thr1462) LS-C354149

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pThr1462) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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Tuberin / TSC2 Antibody (Internal) LS-C413095

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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Tuberin / TSC2 Antibody (p939) LS-C821958

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (p939) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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IHC-plus™ Tuberin / TSC2 Antibody LS-B1432

(4.0) Rating

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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Tuberin / TSC2 Antibody (aa905-954) LS-C117723

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (aa905-954) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Tuberin / TSC2 Antibody LS-C661332

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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Tuberin / TSC2 Antibody (phospho-Thr1462) LS-C808521

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pThr1462) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Tuberin / TSC2 Antibody LS-C801608

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Tuberin / TSC2 Antibody (880-960 aa) LS-C386581

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (880-960 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Tuberin / TSC2 Antibody (Phe933) LS-C176478

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (Phe933) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Human Tuberin / TSC2 (Sandwich ELISA) ELISA Kit - LS-F33459

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat Tuberin / TSC2 (Cell-Based ELISA) ELISA Kit - LS-F2369

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat Phospho-Tuberin / TSC2 (Ser939) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1233

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Tuberin / TSC2 Antibody (aa1611-1807) LS-C343992

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (aa1611-1807) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Tuberin / TSC2 Antibody LS-C500509

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Tuberin / TSC2 Antibody LS-C496666

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389; 200 µl/$503

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Tuberin / TSC2 Antibody (phospho-Ser939) LS-C199699

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer939) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Tuberin / TSC2 Antibody (phospho-Ser1254) LS-C124713

Antibody:

Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer1254) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

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