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TSHB / TSH-Beta
thyroid stimulating hormone, beta
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.
| Gene Name: | thyroid stimulating hormone, beta |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | TSHB, Thyrotropin alfa, Thyrotropin beta subunit, TSH Beta, TSH-B, Thyrotropin beta chain, Thyrotropin subunit beta, TSH-BETA, CHNG4 |
| Target Sequences: | NM_000549 NP_000540.2 P01222 |
Publications (2)
1
MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. The Journal of biological chemistry. 2010 285:34718-28. (IHC-P; Mouse)
[PubMed:20807761]
[PMC:PMC2966087]
2
Thyroid hormone receptor ß sumoylation is required for thyrotropin regulation and thyroid hormone production. Sujie Ke , Yan-Yun Liu, Rajendiran Karthikraj, Kurunthachalam Kannan, Jingjing Jiang , Kiyomi Abe , Anna Milanesi, Gregory A Brent. JCI insight. 2021 Aug;6:e149425. [Full Text Article]
[PubMed:34237030]
[PMC:PMC8410017]
Related Antibodies: LS-C334949.
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TSHB / TSH-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TSHB / TSH-Beta Rabbit anti-Rat Polyclonal (Serum) Antibody
Rat
IHC-R, WB
Unconjugated, Serum
50 µl/$529
Competitive EIA
96-Well Strip Plate
Rat
0.156 - 10 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
10His, N-terminus + Myc, C-terminus
19.9 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
TSHB / TSH-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
Competitive EIA
96-Well Strip Plate
Mouse
0.156 - 10 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
TSHB / TSH-Beta Mouse anti-Mouse Monoclonal (aa21-138) Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
TSHB / TSH-Beta Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
TSHB / TSH-Beta Rabbit anti-Human Polyclonal (aa58-86) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TSHB / TSH-Beta Rabbit anti-Mouse Polyclonal (aa21-138) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TSHB / TSH-Beta Rabbit anti-Mouse Polyclonal (aa21-138) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
TSHB / TSH-Beta Rabbit anti-Mouse Polyclonal (aa21-138) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TSHB / TSH-Beta Rabbit anti-Mouse Polyclonal (aa21-138) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
TSHB / TSH-Beta Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 mg/$688
TSHB / TSH-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TSHB / TSH-Beta Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1 mg/$473
TSHB / TSH-Beta Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
0.5 mg/$797
E. coli
6His, N-terminus
14.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
Yeast
6His, N-terminus + Myc, C-terminus
16.4 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
TSHB / TSH-Beta Mouse anti-Human Monoclonal (TSH 220) Antibody
Human
ICC, IHC
Unconjugated
7 ml/$748
TSHB / TSH-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TSHB / TSH-Beta Sheep anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$697
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