Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Ammonium sulfate precipitation
Radioimmunoassay (1:10000 - 1:30000)
Specificity and Use
TSHB / TSH-Beta antibody was raised against native intact TSH.
Polyclonal antibody is specific for human thyroid stimulating hormone (TSH). TSH production is controlled by a thyrotrophin releasing hormone. The main role of TSH is to stimulate the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). Approximate cross reactivity: hLH <10% hFSH <10% hCG, PRL, hPL <5%.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism.