Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-TYMS mouse monoclonal antibody.
Immunohistochemistry
IHC of paraffin-embedded Human lymphoma tissue using anti-TYMS mouse monoclonal antibody.
Immunohistochemistry
IHC of paraffin-embedded Human tonsil using anti-TYMS mouse monoclonal antibody.
Immunohistochemistry
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-TYMS mouse monoclonal antibody.
Immunohistochemistry
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TYMS mouse monoclonal antibody.
Western blot
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TYMS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TYMS.