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Anti-TRPV4 Antibody (Internal) IHC-plus™ LS-A8583

Ordering

Wt. Vol. Conc. Price
50 µg 50 µl 1 mg/ml $395
Inquire for larger quantities
Same day shipping In Stock - Same day shipping

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TRPV4 Antibodies

Anti-TRPV4 Antibody (Internal) IHC-plus™ LS-A8583
Rabbit Polyclonal to Human TRPV4
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TRPV4 Antibody (aa100-150) LS-C94498
Rabbit Polyclonal to Mouse TRPV4
Mouse, Rat
Unconjugated
Anti-TRPV4 Antibody (Internal) IHC-plus™ LS-B10184
Rabbit Polyclonal (IgG) to Human TRPV4
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed In Stock In Stock Publications Publications (3)
Rabbit Polyclonal to Human TRPV4
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig
IHC - Paraffin, Western blot
Unconjugated

Details

Human TRPV4
Rabbit
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig (tested or 100% immunogen sequence identity)
Rabbit, Chicken (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 - 10 µg/ml)
  • Western blot

Specificity and Use

TRPV4 antibody was raised against synthetic 20 amino acid peptide from internal region of human TRPV4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Bovine, Dog, Horse, Pig (100%); Elephant, Rabbit (95%); Turkey, Chicken, Platypus (90%); Xenopus (85%); Stickleback, Zebrafish (80%).
LS-E29442 - Liquid - 50 µg 1 mg/ml - $145.00
Internal
Human TRPV4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

Publications (3)

1
The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentera RC, Liedtke W, Krizaj D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:7089-101. (WB, IHC-Fr; Mouse, Human) [Full Text Article] [PubMed:21562271] [PMC:PMC3109951]
2
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. American journal of physiology. Heart and circulatory physiology. 2012 Feb;302:H634-42. [Full Text Article] [PubMed:22140047] [PMC:PMC3353785]
3
Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions. Senadheera S, Bertrand PP, Grayson TH, Leader L, Murphy TV, Sandow SL. Journal of anatomy. 2013 Dec;223:677-86. [Full Text Article] [PubMed:24128141]

About TRPV4

Q9HBA0 NM_021625 NP_067638.3

TRPV4 Antibody, CMT2C Antibody, HMSN2C Antibody, OTRPC4 Antibody, SSQTL1 Antibody, VR-OAC Antibody, VRL-2 Antibody, Osm-9-like TRP channel 4 Antibody, SPSMA Antibody, TRP12 Antibody, VRL2 Antibody, VROAC Antibody, SMAL Antibody

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.

Immunohistochemistry

Immunohistochemistry
Anti-TRPV4 antibody LS-A8583 IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
 

Requested From: United States
Date Requested: 12/3/2016

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