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Anti-Trimethylguanosine Synthase 1 Antibody (C-Terminus) IHC-plus™ LS-B255

Note: This antibody replaces LS-C2844

Ordering

Wt. Vol. Conc. Price
100 µg 100 µl 1 mg/ml Unavailable

Most Popular Trimethylguanosine Synthase 1 Antibodies

Anti-Trimethylguanosine Synthase 1 Antibody (C-Terminus) IHC-plus™ LS-B255
Rabbit Polyclonal to Human Trimethylguanosine Synthase 1
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-Trimethylguanosine Synthase 1 Antibody (aa150-200) LS-C286681
Rabbit Polyclonal (IgG) to Human Trimethylguanosine Synthase 1
Human
IHC - Paraffin, Immunofluorescence
Unconjugated
Immunohistochemistry Image
Anti-Trimethylguanosine Synthase 1 Antibody (aa150-200) LS-C287670
Rabbit Polyclonal (IgG) to Human Trimethylguanosine Synthase 1
Human
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human Trimethylguanosine Synthase 1
Human
IHC - Paraffin
Unconjugated

Details

Human Trimethylguanosine Synthase 1
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC - Paraffin (5 µg/ml)

Specificity and Use

Trimethylguanosine Synthase 1 antibody was raised against c terminus of the human PIMT protein
C-Terminus
Reacts with the residues 839-853 of the C terminus of the human PIMT protein.
Immunohistochemistry: LS-B255 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B255 was determined to be 5 ug/ml.

Packaging

PBS, 0.02% sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About Trimethylguanosine Synthase 1

Q96RS0 NM_024831 NP_079107.6

TGS1 Antibody, CLL-associated antigen KW-2 Antibody, HCA137 Antibody, PIMT Antibody, PIPMT Antibody, SEREX-defined Antibody, Trimethylguanosine synthase 1 Antibody, NCOA6IP Antibody, PRIP-interacting protein PIPMT Antibody, Trimethylguanosine synthase Antibody

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Immunohistochemistry

Immunohistochemistry
Anti-TGS1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B255 concentration 5 ug/ml.
 

Requested From: 
Date Requested: 3/27/2017

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