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Trimethylguanosine Synthase 1

trimethylguanosine synthase 1

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Gene Name: trimethylguanosine synthase 1
Synonyms: TGS1, CLL-associated antigen KW-2, HCA137, PIMT, PIPMT, SEREX-defined, Trimethylguanosine synthase 1, NCOA6IP, PRIP-interacting protein PIPMT, Trimethylguanosine synthase
Target Sequences: NM_024831 NP_079107.6 Q96RS0

☰ Filters
Antibodies (16)
Proteins (3)
Primary (16)
Recombinant (3)
Trimethylguanosine Synthase 1 (19)
Human (16)
Mouse (6)
Gibbon (3)
Horse (3)
Monkey (3)
Pig (3)
IHC (12)
IHC-P (6)
WB (10)
ELISA (6)
IP (2)
rabbit (16)
IgG (11)
polyclonal pc (16)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (10)
aa432-481 (4)
aa713-853 (4)
aa150-200 (2)
aa714-853 (1)
aa803-853 (1)
No (19)
GST (2)
His-SUMO (1)
Human (3)
E. coli (1)
Wheat Germ Extract (1)
Purified (1)
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa714-853) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa713-853) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa713-853) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa713-853) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
Trimethylguanosine Synthase 1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa713-853) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
Trimethylguanosine Synthase 1 Antibody - Immunohistochemical analysis of PIMT staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Trimethylguanosine Synthase 1 Antibody - Detection of human PIMT by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti- PIMT used at a dilution of 1:1,000 (1µg/ml). Detection: DAB
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa803-853) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Trimethylguanosine Synthase 1 Antibody - Detection of Human PIMT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-PIMT used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IHC, IP
Unconjugated
2 µg/$295; 100 µl/$514
Trimethylguanosine Synthase 1 Antibody - Detection of Human PIMT by Immunohistochemistry. Sample: FFPE section of human non-small cell lung cancer. Antibody: Affinity purified rabbit anti-PIMT used at a dilution of 1:250. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IHC
Unconjugated
2.5 µg/$295; 100 µl/$532
Trimethylguanosine Synthase 1 Antibody - TGS1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa432-481) Antibody
Human
WB
Unconjugated
100 µl/$424
Trimethylguanosine Synthase 1 Antibody - TGS1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa432-481) (HRP) Antibody
Mouse, Pig, Horse, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
Trimethylguanosine Synthase 1 Antibody - TGS1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa432-481) (Biotin) Antibody
Mouse, Pig, Horse, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
Trimethylguanosine Synthase 1 Antibody - TGS1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Trimethylguanosine Synthase 1 Rabbit anti-Human Polyclonal (aa432-481) (FITC) Antibody
Mouse, Pig, Horse, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
Trimethylguanosine Synthase 1 Protein
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Trimethylguanosine Synthase 1 Protein
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E. coli
His-SUMO
31.64 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Trimethylguanosine Synthase 1 Protein - 12.5% SDS-PAGE of human NCOA6IP stained with Coomassie Blue
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Wheat Germ Extract
GST
41.25 kDa
10 µg/$479; 25 µg/$670
Viewing 1-19 of 19 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).