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E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA.
Gene Name: | tripartite motif containing 56 |
Synonyms: | TRIM56, RNF109, Tripartite motif-containing 56, RING finger protein 109, Tripartite motif containing 56 |
Target Sequences: | AL512757 CAC21676.1 Q9BRZ2 |
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