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TRIM28 / KAP1
tripartite motif containing 28
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
| Gene Name: | tripartite motif containing 28 |
| Family/Subfamily: | Tripartite Motif , TIF1 |
| Synonyms: | TRIM28, E3 SUMO-protein ligase TRIM28, KRIP-1, Nuclear corepressor KAP-1, KAP-1, KAP1, KRAB-interacting protein 1, TIF1B, RNF96, TIF1-beta, TIF1beta, Tripartite motif-containing 28, KRAB-associated protein 1, RING finger protein 96, TF1B, Tif1beta zinc finger protein, Tripartite motif containing 28 |
| Target Sequences: | NM_005762 NP_005753.1 Q13263 |
Publications (1)
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