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E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Gene Name: | tripartite motif containing 13 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM13, DLEU5, CLL-associated RING finger, LEU5, Leukemia-associated protein 5, RING finger protein 77, Tripartite motif protein 13, Putative tumor suppressor RFP2, RFP2, CAR, Ret finger protein 2, RNF77, Tripartite motif containing 13, Tripartite motif-containing 13 |
Target Sequences: | NM_005798 NP_005789.2 O60858 |
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