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Anti-TRF1 / TERF1 Antibody (clone BED5) IHC-plus™ LS-B5949

Note: This antibody replaces LS-C58225

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

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Most Popular TRF1 / TERF1 Antibodies

Anti-TRF1 / TERF1 Antibody (clone BED5) IHC-plus™ LS-B5949
Mouse Monoclonal [clone BED5] (IgG1) to Human TRF1 / TERF1
Human
IHC - Paraffin, IHC - Frozen, ELISA
Unconjugated
Immunohistochemistry Image

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Mouse Monoclonal [clone BED5] (IgG1) to Human TRF1 / TERF1
Human
IHC - Paraffin, IHC - Frozen, ELISA
Unconjugated

Details

Human TRF1 / TERF1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [BED5]
Unconjugated
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • ELISA

Specificity and Use

TRF1 / TERF1 antibody was raised against recombinant TRF1
Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose Histology Positive Control Tissue: Human tonsil.

Packaging

PBS containing 0.09% sodium azide. Sourced in TCS.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About TRF1 / TERF1

P54274 NM_017489 NP_059523.2

TERF1 Antibody, HTRF1-AS Antibody, NIMA-interacting protein 2 Antibody, PIN2 Antibody, Telomeric protein Pin2/TRF1 Antibody, TRBF1 Antibody, TTAGGG repeat-binding factor 1 Antibody, T-TRF1 Antibody, TRF Antibody, TRF1 Antibody

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection.

Immunohistochemistry

Immunohistochemistry
Anti-TRF1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5949 concentration 10 ug/ml.
 

Requested From: United States
Date Requested: 12/9/2016

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