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TRAIL-R3 / DCR1
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
| Gene Name: | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF10C, CD263 antigen, CD263, Cytotoxic TRAIL receptor-3, Decoy receptor 1, DCR1, DCR1-TNFR, LIT, Lymphocyte inhibitor of TRAIL, TRAIL-R3, TRAILR3, TRAIL receptor 3, TRID |
| Target Sequences: | NM_003841 NP_003832.2 O14798 |
Publications (1)
1
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Fung KL. Experimental cell research. 2015 August;336:318-28. (Human)
[Full Text Article]
[PubMed:26101157]
[PMC:PMC4522412]
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TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (TR3.06) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µg/$470
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
TRAIL-R3 / DCR1 Rabbit anti-Human Monoclonal (Preservative Free) (003) Antibody
Human
Flo
Unconjugated, Preservative Free
100 µl/$412
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal (aa32-244) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
TRAIL-R3 / DCR1 Goat anti-Human Polyclonal (aa33-63) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$556
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
TRAIL-R3 / DCR1 Rabbit anti-C. elegans Polyclonal (aa1068-1097) Antibody
C. elegans
ELISA
Unconjugated
200 µl/$734
TRAIL-R3 / DCR1 Rabbit anti-C. elegans Polyclonal (aa1068-1097) (Biotin) Antibody
ELISA, WB
Biotin Conjugated
200 µl/$952
TRAIL-R3 / DCR1 Rabbit anti-C. elegans Polyclonal (aa1068-1097) (FITC) Antibody
ELISA, WB
FITC Conjugated
200 µl/$952
TRAIL-R3 / DCR1 Rabbit anti-C. elegans Polyclonal (aa1068-1097) (APC) Antibody
ELISA, WB
APC Conjugated
200 µl/$952
TRAIL-R3 / DCR1 Rabbit anti-Human Monoclonal (PE) (003) Antibody
Human
Flo
PE Conjugated
25 Tests/$278; 100 Tests/$421
TRAIL-R3 / DCR1 Rabbit anti-Human Monoclonal (APC) (003) Antibody
Human
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$421
TRAIL-R3 / DCR1 Rabbit anti-Human Monoclonal (FITC) (003) Antibody
Human
Flo
FITC Conjugated
25 Tests/$278; 100 Tests/$421
Sandwich
96-Well Microplate
Human
16.38 - 1600 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (AT1E12) Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (HS301) Antibody
Human
Flo, ICC
Unconjugated
100 µg/$470
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$444; 100 µg/$597
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$688
TRAIL-R3 / DCR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$755
TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (FITC) (TRAIL-R3-02) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$400
TRAIL-R3 / DCR1 Mouse anti-Human Monoclonal (PE) (TRAIL-R3-02) Antibody
Human
Flo
PE Conjugated
0.1 mg/$449
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