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TPX2

TPX2, microtubule-associated

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.

Gene Name: TPX2, microtubule-associated
Synonyms: TPX2, C20orf2, DIL-2, DIL2, HCA519, GD:C20orf1, p100, Protein fls353, Targeting protein for Xklp2, C20orf1, FLS353, HCTP4, REPP86
Target Sequences: NM_012112 NP_036244.2 Q9ULW0

Publications (6)

1
Tumor cell dependence on Ran-GTP-directed mitosis. Xia F, Lee CW, Altieri DC. Cancer research. 2008 68:1826-33. [PubMed:18339863]
2
A survivin-ran complex regulates spindle formation in tumor cells. Xia F, Canovas PM, Guadagno TM, Altieri DC. Molecular and cellular biology. 2008 28:5299-311. [PubMed:18591255] [PMC:PMC2519733]
3
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. Bird AW, Hyman AA. The Journal of cell biology. 2008 182:289-300. [PubMed:18663142] [PMC:PMC2483532]
4
Identification of a physiological E2 module for the human anaphase-promoting complex. Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH, Rape M. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:18213-8. [PubMed:19822757] [PMC:PMC2775311]
5
Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Ma N, Tulu US, Ferenz NP, Fagerstrom C, Wilde A, Wadsworth P. Molecular biology of the cell. 2010 21:979-88. (ICC; Pig) [PubMed:20110350] [PMC:PMC2836978]
6
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Trakala M, Fernández-Miranda G, Pérez de Castro I, Heeschen C, Malumbres M. Cell cycle (Georgetown, Tex.). 2013 12:1030-41. (WB; Mouse) [Full Text Article] [PubMed:23428904] [PMC:PMC3646860] Related Antibodies: LS-B146.
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☰ Filters
Antibodies (56)
Proteins (4)
Over-Expression Lysate (2)
Primary (56)
Recombinant (2)
TPX2 (60)
Human (55)
Mouse (25)
Rat (6)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Frog (1)
Gibbon (3)
Guinea pig (3)
Horse (3)
Mammal (1)
Monkey (3)
Orangutan (3)
Pig (4)
Rabbit (3)
IHC (18)
IHC-P (8)
WB (51)
Flo (4)
DB (2)
ELISA (33)
ICC (5)
IF (5)
IP (8)
Peptide-ELISA (3)
rabbit (35)
mouse (21)
Product Group
IHCPlus (5)
IgG (30)
IgG1 (18)
IgG1,k (2)
monoclonal mc (21)
polyclonal pc (35)
1696CT464.66.9 (1)
18D5 (1)
19AT738.292 (1)
19AT953.286.93 (1)
1D4B (1)
3164C6a (2)
TPX2-01 (1)
APC Conjugated (4)
Azide-free (4)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (30)
aa350-382 (7)
aa419-448 (7)
aa651-700 (4)
C-Terminus (2)
270-350 aa, Internal (1)
aa1-220 (1)
aa15-93 (1)
aa150-200 (1)
aa281-330 (1)
aa301-350 (1)
aa700-C-term (1)
No (59)
Yes (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
TPX2 Antibody - Anti-TPX2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IHC-plus™ TPX2 Antibody (C-Terminus) LS-B146
(5.0) Rating
(1) Publication(s)
TPX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Pig, Mammal, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
TPX2 Antibody - Anti-TPX2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IHC-plus™ TPX2 Antibody (clone 18D5) LS-B1910
(4.0) Rating
TPX2 Mouse anti-Human Monoclonal (18D5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
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TPX2 Antibody (C-Terminus) LS-C90644
TPX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
Flo, IF, IP, WB
Unconjugated
100 µl/$649
TPX2 Antibody - Detection of human TPX2 by Western blot. Samples: Whole cell lysate (25 ug) from HeLa cells. Predicted molecular weight: 85 kDa
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TPX2 Antibody (clone 3164C6a) LS-C342496
TPX2 Mouse anti-Human Monoclonal (3164C6a) Antibody
Human
DB, Flo, ICC, IP, WB
Unconjugated
100 µg/$486
TPX2 Antibody - Anti-TPX2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IHC-plus™ TPX2 Antibody (aa301-350) LS-B5672
(4.0) Rating
TPX2 Rabbit anti-Human Polyclonal (aa301-350) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
TPX2 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ TPX2 Antibody (clone 19AT738.292) LS-B11806
(4.0) Rating
TPX2 Mouse anti-Human Monoclonal (19AT738.292) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
TPX2 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ TPX2 Antibody (aa281-330) LS-B12484
(4.0) Rating
TPX2 Rabbit anti-Human Polyclonal (aa281-330) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
TPX2 Antibody - 1:100 staining rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TPX2 Antibody LS-C810265
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TPX2 Antibody LS-C76463
TPX2 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IP, WB
Unconjugated
100 µg/$786
TPX2 Antibody - Immunofluorescent staining using TPX2 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-TPX2 antibody. Nuclear was stained with Hoechst (blue fluorescence).
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TPX2 Antibody (clone 3164C6a) LS-C184453
TPX2 Mouse anti-Human Monoclonal (3164C6a) Antibody
Human
DB, Flo, ICC, IP, WB
Unconjugated
100 µg/$965
TPX2 Antibody - Detection of Human TPX2 by Immunocytochemistry. Sample: Formaldehyde-fixed asynchronous HeLa cell. Antibody: Affinity purified rabbit anti-TPX2 used at a dilution of 1:400 (2.5 ug/ml). Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain, cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1:100.
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TPX2 Antibody (aa150-200) LS-C287321
TPX2 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
ICC, IF, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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TPX2 Antibody LS-C661205
TPX2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$341
TPX2 Antibody - Western blotting analysis of TPX2 using monoclonal antibody TPX2-01 in A) human cell lines, B) murine (P19, NIH 3T3, Neuro-2a) and rat (RBL-2H3, L6) cell lines.
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TPX2 Antibody (clone TPX2-01) LS-C742200
TPX2 Mouse anti-Human Monoclonal (TPX2-01) Antibody
Mouse, Rat, Human
ELISA, ICC, IHC-P, IP, WB
Unconjugated
0.1 mg/$330
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TPX2 Antibody (aa1-220, clone 1D4B) LS-C189761
TPX2 Mouse anti-Human Monoclonal (aa1-220) (1D4B) Antibody
Human
IF, IHC, WB
Unconjugated
100 µg/$587
TPX2 Antibody - Immunohistochemistry image at a dilution of 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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TPX2 Antibody LS-C673551
TPX2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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TPX2 Antibody (aa350-382) LS-C328918
TPX2 Rabbit anti-Human Polyclonal (aa350-382) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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TPX2 Antibody (aa350-382, Biotin) LS-C246478
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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TPX2 Antibody (aa350-382, FITC) LS-C246184
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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TPX2 Antibody (aa350-382, APC) LS-C246183
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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TPX2 Antibody (aa350-382, PE) LS-C246186
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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TPX2 Antibody (aa350-382, Azide-free, HRP) LS-C247933
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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TPX2 Antibody LS-C771351
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TPX2 Antibody - Western blot of TPX2 antibody
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TPX2 Antibody (270-350 aa, Internal) LS-C386479
TPX2 Rabbit anti-Human Polyclonal (270-350 aa, Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TPX2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using DIL-2 antibody.
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TPX2 Antibody LS-C823297
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TPX2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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TPX2 Antibody (aa350-382) LS-C97707
TPX2 Rabbit anti-Human Polyclonal (aa350-382) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Viewing 1-25 of 60 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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