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TPM1 / Tropomyosin

tropomyosin 1 (alpha)

TPM1 / Tropomyosin is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Gene Name: tropomyosin 1 (alpha)
Synonyms: TPM1, Alpha-tropomyosin, C15orf13, Cardiomyopathy, hypertrophic 3, CMD1Y, CMH3, HTM-alpha, Sarcomeric tropomyosin kappa, TMSA, Tropomyosin, Tropomyosin 1 (alpha), Tropomyosin alpha-1 chain, Tropomyosin-1
Target Sequences: NM_000366 NP_000357.3 P09493

Publications (2)

1
Transcriptomic Profiling of the Liver Sinusoidal Endothelium during Cirrhosis Reveals Stage-Specific Secretory Signature. Nicolò Manicardi, Anabel Fernández-Iglesias, Laia Abad-Jordà, Felix Royo, Mikel Azkargorta, Martí Ortega-Ribera, David Sanfeliu-Redondo, Ana Martínez-Alcocer, Felix Elortza, Amelia J Hessheimer, Constantino Fondevila, Juan José Lozano, Juan Carlos García-Pagán, Jaime Bosch, Francisco Javier Cubero, Agustín Albillos, Javier Vaquero, Juan M Falcón-Pérez, Jordi Gracia-Sancho. Cancers. 2021 May;13: [Full Text Article] [PubMed:34072510] [PMC:PMC8198220]
2
Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria. Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fr[Character f6]hlich T, Arnold GJ, Wanke R. Proteomics. Clinical applications. 2011 Jun;5:375-81. [Full Text Article] [PubMed:21538912] Related Antibodies: LS-C31829.

☰ Filters
Antibodies (35)
Proteins (25)
Over-Expression Lysate (12)
Primary (35)
Recombinant (13)
TPM1 / Tropomyosin (60)
Human (31)
Mouse (20)
Rat (19)
Bat (3)
Bovine (3)
Charybdis feriata (4)
Chicken (9)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (6)
Orangutan (3)
Pig (3)
Rabbit (8)
Xenopus (3)
Zebrafish (8)
IHC (11)
IHC-Fr (1)
IHC-P (7)
WB (26)
ELISA (9)
IF (2)
IP (4)
Peptide-ELISA (2)
rabbit (29)
mouse (6)
Product Group
IHCPlus (2)
IgG (18)
IgG1 (3)
IgG2a (3)
monoclonal mc (6)
polyclonal pc (29)
TM-33 (3)
TM-36 (3)
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FITC Conjugated (4)
HRP Conjugated (4)
Magnetic beads Conjugated (2)
Sepharose Conjugated (2)
Unconjugated (19)
C-Terminus (4)
N-Terminus (4)
aa20-69 (4)
Glu40 (1)
N-Terminal (1)
aa1-264 (1)
aa40-89 (1)
pSer283 (1)
No (58)
Yes (2)
10His, N-terminus + Myc, C-terminus (2)
6His, N-terminus + Myc, C-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
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Myc-DDK (Flag) (18)
Dermatophagoides farinae (1)
Human (15)
Rabbit (3)
293T Cells (6)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (12)
Wheat Germ Extract (2)
Yeast (1)
Purified (6)
Select
TPM1 / Tropomyosin Rabbit anti-Charybdis feriata Polyclonal (aa1-264) Antibody
Charybdis feriata
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody ARP41392_T100-NP_000357-TPM1(tropomyosin 1 (alpha)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (aa20-69) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody ARP41392_T100-NP_000357-TPM1(tropomyosin 1 (alpha)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (aa20-69) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody ARP41392_T100-NP_000357-TPM1(tropomyosin 1 (alpha)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (aa20-69) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody ARP41392_T100-NP_000357-TPM1(tropomyosin 1 (alpha)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (aa20-69) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
TPM1 / Tropomyosin Antibody - Anti-Tropomyosin 1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TPM1 / Tropomyosin Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (pSer283) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$567
TPM1 / Tropomyosin Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Zebrafish, Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody Western blot of Fetal Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
WB
Unconjugated
100 µl/$424
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody Western blot of Fetal Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Monkey
WB
HRP Conjugated
100 µl/$469
TPM1 / Tropomyosin Antibody - TPM1 / Tropomyosin antibody Western blot of Fetal Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Monkey
WB
FITC Conjugated
100 µl/$469
TPM1 / Tropomyosin Antibody - Western blot of TPM1 Antibody with human 721_B Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
TPM1 / Tropomyosin Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using TPM1 Polyclonal Antibody at dilution of 1:40.
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TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TPM1 / Tropomyosin Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using TPM1 Polyclonal Antibody at dilution of 1:80.
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TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
TPM1 / Tropomyosin Mouse anti-Chicken Monoclonal (TM-36) Antibody
Chicken, Rabbit, Human
IHC, IHC-Fr, WB
Unconjugated
100 µg/$380
TPM1 / Tropomyosin Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Zebrafish, Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TPM1 / Tropomyosin Antibody - Western blot of TPM1 pAb in extracts from HT-1080 cells and mouse heart tissue.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
TPM1 / Tropomyosin Antibody - Western blot of Tropomyosin alpha antibody
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TPM1 / Tropomyosin Antibody - Western Blot analysis of 1, mouse-lung, 2, mouse-brain, 3, mouse-spleen cells using primary antibody diluted at 1:500 (4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800 (diluted at 1:5000, 25°C, 1 hour).
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TPM1 / Tropomyosin Antibody - Western blot analysis of lysate from HeLa cells, using Tropomyosin α antibody.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (aa40-89) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal (Glu40) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
TPM1 / Tropomyosin Mouse anti-Chicken Monoclonal (TM-33) Antibody
Chicken, Mouse, Rat, Human
WB
Unconjugated
100 µg/$380
TPM1 / Tropomyosin Antibody - Immunochemical staining of human TPM1 in human skeletal muscle with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Select
TPM1 / Tropomyosin Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
Viewing 1-25 of 60 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).