Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
TPBG is a transmembrane glycoprotein first identified by a monoclonal antibody (mAb5TA) raised against human trophoblast glycoproteins. The protein is concentrated at microvillus projections of the plasma membrane and over expression in epithelial cells is associated with changes in morphology and increased motility. The cytoplasmic domain has been shown to influence actin/cadherin contacts. TPBG positive carcinomas have been shown to have an increased mortality rate.