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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TP53BP1 / 53BP1 Antibody (C‑Terminus) LS‑C49071
53BP1 antibody LS-C49071 is an unconjugated rabbit polyclonal antibody to 53BP1 (TP53BP1) from human, mouse and rat. Validated for ICC, IHC and WB.
Catalog
Size
Price
LS-C49071-100
100 µg
Unavailable

Popular TP53BP1 / 53BP1 Products

Anti-TP53BP1 / 53BP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B315 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, ICC, Western blot
Anti-TP53BP1 / 53BP1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1714 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Anti-TP53BP1 / 53BP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6175 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Goat, Fish, Primate
Applications: IHC, IHC - Paraffin
Detection of Human and Mouse Phospho 53BP1 (S25) by Immunohistochemistry. Sample: FFPE sections of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti- Phospho 53bp1 (S25) used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Species: Human, Mouse, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry, Proximity Ligation Assay
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

53BP1 antibody LS-C49071 is an unconjugated rabbit polyclonal antibody to 53BP1 (TP53BP1) from human, mouse and rat. Validated for ICC, IHC and WB.
About TP53BP1 / 53BP1
Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks. Q12888 NM_005657 NP_005648.1

TP53BP1 Antibody, 53BP1 Antibody, p202 Antibody, p53-binding protein 1 Antibody, p53-binding protein 53bp1 Antibody, p53BP1 Antibody


Specifications

Target
Human TP53BP1 / 53BP1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, DY650, DY488, DY550.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • ICC (1:50 - 1:1000)
  • Western blot (1:200 - 1:10000)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
TP53BP1 / 53BP1 antibody was raised against the epitope recognized by this antibody maps to a region between residues 1925 and the C-terminus (residue 1972) of human tumor protein p53 binding protein 1 (NP_005648.1)
Epitope
C-Terminus
Specificity
human 53BP1 protein.
Presentation
PBS, 0.05% sodium azide
Storage
4°C, avoid freezing.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Placenta Villi 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Placenta Villi 40X. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunocytochemistry

Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Placenta Villi 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Placenta Villi 40X. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunocytochemistry

Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Placenta Villi 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Placenta Villi 40X. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunocytochemistry

Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Placenta Villi 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Placenta Villi 40X. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunocytochemistry

Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of human 53BP1. Sample: Whole cell lysate (20 ug/lane) from U2Os cells resolved on a 3 to 8% Tris acetate gel. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/22/2018

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