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Anti-TP53 / p53 Antibody (clone Pab122) LS-C202480

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $265
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular TP53 / p53 Antibodies

Anti-TP53 / p53 Antibody (clone BP53-12) IHC-plus™ LS-B431
Mouse Monoclonal [clone BP53-12] (IgG2a,k) to Human TP53 / p53
Human
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-TP53 / p53 Antibody (clone PAb240, Azide-free) LS-C87442
Mouse Monoclonal [clone PAb240] (IgG1) to Mouse TP53 / p53
Mouse, Human
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-TP53 / p53 Antibody (clone 6F2D3) LS-C203312
Mouse Monoclonal [clone 6F2D3] (IgG1) to Human TP53 / p53
Human
Western blot, Flow Cytometry, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone Pab122] (IgG1,k) to Human TP53 / p53
Human
IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry, ELISA
Unconjugated

Details

Human TP53 / p53
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [Pab122]
Unconjugated
Purified
Unmodified

Applications

  • IHC - Paraffin
  • IHC - Frozen
  • Western blot
  • Flow Cytometry
  • ELISA

Specificity and Use

TP53 / p53 antibody was raised against recombinant human p53 protein. Splenocytes were fused with mouse myeloma P3-X63/AG8.653 cells.
The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). P53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

Packaging

PBS, 0.05% sodium azide
Store at 4°C.
For research use only.

About TP53 / p53

P04637 NM_000546 NP_000537.3

TP53 Antibody, BCC7 Antibody, Cellular tumor antigen p53 Antibody, p53 Antibody, TRP53 Antibody, p53 tumor suppressor Antibody, Phosphoprotein p53 Antibody, Antigen NY-CO-13 Antibody, Tumor protein p53 Antibody, Tumor suppressor p53 Antibody, LFS1 Antibody

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases.

Requested From: United States
Date Requested: 12/10/2016

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