P53 antibody LS-C11553 is an unconjugated mouse monoclonal antibody to p53 (TP53) from human, bovine, cat and other species. Validated for ELISA, IHC, IP and WB. Cited in 1 publication.
Human, Bovine, Cat, Horse
(tested or 100% immunogen sequence identity)
Protein G purified
- IHC - Paraffin (1:25)
- IHC - Frozen
- Western blot (1:1000)
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TP53 / p53 antibody was raised against recombinant human p53 ( AA 20-25 ).
Recognizes the human p53 tumor suppressor protein, also known as cellular tumor antigen p53 or NY-CO-13. Clone DO-1 binds to both wild type and mutant forms of the p53 protein found in various malignancies. p53 is important in multicellular organisms, where it regulates cell cycle progression to allow DNA repair or apoptosis in the case of irreparably damaged cells and thus functions as a tumor suppressor that is involved in preventing cancer. Mutations in the p53 gene are found in about half the cases of human cancerrecognizes an epitope at the N-terminal end of p53 between amino acids 20-25, common to isoforms 1-3 of p53.
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. We recommend the use of 0.01 M citrate buffer for this purpose.
PBS, 0.09% Sodium Azide
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
For research use only.