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TP53 / p53
tumor protein p53
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
| Gene Name: | tumor protein p53 |
| Family/Subfamily: | P53 , Not assigned-Other |
| Synonyms: | TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1 |
| Target Sequences: | NM_000546 NP_000537.3 P04637 |
Publications (9)
1
Cancer. p53, guardian of the genome. Lane DP. Nature. 1992 358:15-6.
[PubMed:1614522]
Related Antibodies: LS-B431.
2
p53 mutations in human cancers. Hollstein M, Sidransky D, Vogelstein B, Harris CC. Science (New York, N.Y.). 1991 253:49-53.
[PubMed:1905840]
Related Antibodies: LS-B431.
3
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. Gurney EG, Harrison RO, Fenno J. Journal of virology. 1980 34:752-63.
[PubMed:6155477]
[PMC:PMC288763]
Related Antibodies: LS-B431.
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(9)
aa108-370
(8)
aa134-387
(8)
aa90-354
(8)
Ser15
(7)
Ser315
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Thr55
(7)
aa354-385
(7)
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(7)
320-400 aa
(6)
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(6)
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(6)
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(5)
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(5)
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(5)
1-80 aa
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pSer366
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aa371-380
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p53
(2)
pSer376
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pSer378
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250-330 aa
(1)
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300-380 aa
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Acetyl-Lys319
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Acetyl-Lys370
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Arg375
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Ser371
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Ser46
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Ser9
(1)
Val31
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aa1-30
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aa1-50
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aa10-59
(1)
aa11-60
(1)
aa14-389
(1)
aa15-40
(1)
aa15-64
(1)
aa16-30
(1)
aa16-65
(1)
aa181-190
(1)
aa187-215
(1)
aa26-75
(1)
aa283-332
(1)
aa301-350
(1)
aa314-342
(1)
aa320-369
(1)
aa322-371
(1)
aa325-375
(1)
aa331-380
(1)
aa334-383
(1)
aa341-390
(1)
aa35-45
(1)
aa375-C-term
(1)
aa6-55
(1)
aa74-393
(1)
aa8-57
(1)
acetylation site of K370.
(1)
acetylation site of K373.
(1)
around the acetylation site of K320.
(1)
di-methylation site of K370
(1)
p15
(1)
p18
(1)
p20
(1)
p315
(1)
p33
(1)
p37
(1)
Publications
No
(669)
Yes
(6)
Sample Type
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(12)
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(2)
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Human
(18)
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(2)
Rat
(2)
Source
293T Cells
(4)
E. coli
(9)
HEK 293 Cells
(8)
Sf9 Cells
(1)
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(3)
Yeast
(1)
Purification
Purified
(6)
TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human
ChrIP, ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
Cancer Pathology
Cancer
TP53 / p53 Rabbit anti-Human Polyclonal (aa283-332) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TP53 / p53 Mouse anti-Human Monoclonal (aa20-25) (DO-1) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$395
TP53 / p53 Rabbit anti-Human Polyclonal (aa344-393) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Rabbit anti-Human Polyclonal (di-methylation site of K370) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TP53 / p53 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TP53 / p53 Mouse anti-Human Monoclonal (aa181-190) (DO-11) Antibody
Human
IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$444
TP53 / p53 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
0.25 ml/$393
E. coli
His, N-Terminal
33.4 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
E. coli
His-SUMO
59.1 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
6His, N-terminus
46.3 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
TP53 / p53 Rabbit anti-Human Polyclonal (Acetyl-Lys379) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb 122) Antibody
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
50 µg/$384; 200 µg/$574
TP53 / p53 Mouse anti-Human Monoclonal (OTI3A6) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
TP53 / p53 Mouse anti-Human Monoclonal (N-Terminus) (Bp53.11) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
50 mg/$711
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Unconjugated
100 µg/$411
TP53 / p53 Mouse anti-Mouse Monoclonal (Biotin) (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Biotin Conjugated
100 µg/$446
TP53 / p53 Mouse anti-Human Monoclonal (aa16-30) Antibody
Xenopus, Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$466
TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human, Primate
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated
25 µg/$276; 100 µg/$352
TP53 / p53 Mouse anti-Human Monoclonal (OTI5E2) Antibody
Mouse, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Rabbit, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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