TOP3B

topoisomerase (DNA) III beta

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.

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Products

Antibodies (21)

Proteins (2)

Type

Primary (21)

Recombinant (2)

Target

TOP3B (23)

Reactivity

Human (21)

Mouse (12)

Rat (2)

Bovine (1)

Dog (1)

Pig (1)

Application

IHC (2)

IHC-P (1)

WB (21)

ELISA (8)

IF (1)

IP (1)

Peptide-ELISA (2)

Host

rabbit (21)

Isotype

IgG (11)

Clonality

polyclonal pc (21)

Format

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (9)

Epitope

aa826-854 (7)

30-110 aa, N-terminal (1)

N-Terminus (1)

aa51-100 (1)

Publications

No (23)

Tag

GST (1)

His-T7, N-terminus (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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TOP3B Antibody (N-Terminus) LS-C353109

Antibody:

TOP3B Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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TOP3B Antibody (30-110 aa, N-terminal) LS-C386460

Antibody:

TOP3B Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TOP3B Antibody LS-C804456

Antibody:

TOP3B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TOP3B Antibody (aa826-854) LS-C325863

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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TOP3B Antibody (aa826-854, Biotin) LS-C224383

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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TOP3B Antibody (aa826-854, FITC) LS-C224384

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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TOP3B Antibody (aa826-854, APC) LS-C224382

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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TOP3B Antibody (aa826-854, Azide-free, HRP) LS-C224385

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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TOP3B Antibody (aa826-854, PE) LS-C224386

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

TOP3B Antibody LS-C822533

Antibody:

TOP3B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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TOP3B Antibody (aa51-100) LS-C118743

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa51-100) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TOP3B Antibody (aa826-854) LS-C160117

Antibody:

TOP3B Rabbit anti-Human Polyclonal (aa826-854) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

TOP3B Antibody LS-C663419

Antibody:

TOP3B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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TOP3B Antibody (HRP) LS-C712758

Antibody:

TOP3B Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

Select

TOP3B Antibody (Biotin) LS-C688102

Antibody:

TOP3B Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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TOP3B Antibody (FITC) LS-C695021

Antibody:

TOP3B Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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TOP3B Antibody (Cy3) LS-C703736

Antibody:

TOP3B Rabbit anti-Human Polyclonal (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

TOP3B Antibody (APC) LS-C741180

Antibody:

TOP3B Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

TOP3B Antibody (APC, Cy7) LS-C735743

Antibody:

TOP3B Rabbit anti-Human Polyclonal (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

Select

TOP3B Antibody (PE) LS-C726819

Antibody:

TOP3B Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• APC, Cy7
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • APC, Cy7
  • PE

Select

TOP3B Antibody LS-C410004

Antibody:

TOP3B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

Human TOP3B Protein (Recombinant GST) (Full Length) - LS-G31410

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

120.56 kDa

Price:

2 µg/$439

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Human TOP3B Protein (Recombinant His-T7, N-terminus) (Met1-Asp250) - LS-G133414

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

31.6kDa

Price:

10 µg/$272; 50 µg/$382; 200 µg/$765; 100 µg/$612; 1 mg/$1,822; 500 µg/$1,383; 5 mg/$2,781; 2 mg/$2,004

Viewing 1-23 of 23 product results

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