Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
A synthetic peptide, corresponding to aa 1513-1530 (RAKKPIKYLEESDEDDLF) from the C-terminus of human topoisomerase IIalpha. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Panda, Rabbit (100%); Marmoset, Hamster, Elephant, Porcine, Horse, Opossum (94%); Rat, Bat (89%).
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
TOP2A Antibody, DNA topoisomerase II, 170 kD Antibody, TOP2 Antibody, DNA gyrase Antibody, DNA topoisomerase 2-alpha Antibody, TP2A Antibody
TOP2A / Topoisomerase II Alpha is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.