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Anti-TNNI3 / Cardiac Troponin I Antibody (aa130-145, clone M46) LS-C52547
Mouse Monoclonal (IgG1) to Human TNNI3 / Cardiac Troponin I
Human
Western blot, ELISA
Biotin Conjugated
Mouse Monoclonal [clone M46] (IgG1) to Human TNNI3 / Cardiac Troponin I
Human
IHC, Western blot, Immunoprecipitation
Unconjugated
Details
Human TNNI3 / Cardiac Troponin I
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [M46]
Unconjugated
Protein A purified
Unmodified
Applications
IHC
Western blot
Immunoprecipitation
Specificity and Use
Free human cTnI, native human cTn complex, or human cTnI peptides.
aa130-145
All MAbs (except M46, 267, 596 and C5) have no cross-reaction with skeletal muscle TnI. Cross-reactivity with skeletal TnI is less than 10 % MAbs M46, 267 and 596, and more than 50 % MAb C5. MAb 247 reacts only with free cTnI. Additional comprehensive inmation about cross-reactivity with different ms of antigens (phosphorylated, complexed etc.) and antigens from different species (rat, mouse, canine, bovine and porcine) is available.
TNNI3 Antibody, CTnI Antibody, CMD1FF Antibody, CMD2A Antibody, RCM1 Antibody, Troponin I, cardiac Antibody, Troponin I, cardiac muscle Antibody, Troponin I type 3 (cardiac) Antibody, Cardiac troponin I Antibody, CMH7 Antibody
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues.