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Anti-TNNI3 / Cardiac Troponin I Antibody (aa130-145, clone M46) LS-C52547

Note: This antibody replaces LS-C89761, LS-C39912

Catalog	Size	Price
LS-C52547-200	200 µg	Unavailable

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Antibody:	Mouse Monoclonal [clone M46] (IgG1) to Human TNNI3 / Cardiac Troponin I
Reactivity:	Human
Application:	IHC, Western blot, Immunoprecipitation
Format:	Unconjugated

Details

Target:	Human TNNI3 / Cardiac Troponin I
Host:	Mouse
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	IgG1 Monoclonal [M46]
Conjugations:	Unconjugated
Purification:	Protein A purified
Modifications:	Unmodified

Applications

Approved:

IHC
Western blot
Immunoprecipitation

Specificity and Use

Immunogen:	Free human cTnI, native human cTn complex, or human cTnI peptides.
Epitope:	aa130-145
Specificity:	All MAbs (except M46, 267, 596 and C5) have no cross-reaction with skeletal muscle TnI. Cross-reactivity with skeletal TnI is less than 10 % MAbs M46, 267 and 596, and more than 50 % MAb C5. MAb 247 reacts only with free cTnI. Additional comprehensive inmation about cross-reactivity with different ms of antigens (phosphorylated, complexed etc.) and antigens from different species (rat, mouse, canine, bovine and porcine) is available.

Packaging

Presentation:	PBS, pH 7.4, 0.1 % sodium azide.
Storage:	+4°C, avoid freezing.
Restrictions:	For research use only.

About TNNI3 / Cardiac Troponin I

Uniprot: P19429 NCBI: NM_000363 NP_000354.4

Synonyms: TNNI3 Antibody, CTnI Antibody, CMD1FF Antibody, CMD2A Antibody, RCM1 Antibody, Troponin I, cardiac Antibody, Troponin I, cardiac muscle Antibody, Troponin I type 3 (cardiac) Antibody, Cardiac troponin I Antibody, CMH7 Antibody

Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues.

(More About TNNI3 / Cardiac Troponin I)

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