TNK2 / ACK1

tyrosine kinase, non-receptor, 2

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

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Products

Antibodies (54)

ELISA Kits (6)

Proteins (5)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (54)

Recombinant (3)

Sandwich (4)

Sandwich CLIA (1)

Target

TNK2 / ACK1 (65)

Reactivity

Human (58)

Mouse (14)

Rat (8)

Bovine (1)

Monkey (1)

Pig (1)

Application

IHC (19)

IHC-P (8)

WB (38)

Flo (1)

DB (14)

ELISA (34)

ICC (1)

IF (9)

Peptide-ELISA (7)

Host

rabbit (54)

Product Group

IHCPlus (2)

Isotype

IgG (46)

Clonality

polyclonal pc (54)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (3)

APC Conjugated (4)

Azide-free (4)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (4)

Unconjugated (34)

Epitope

pTyr518 (8)

aa265-290 (7)

aa934-964 (7)

pTyr284 (7)

pTyr826 (7)

220-300 aa (2)

Ab-284 (1)

aa10-39 (1)

aa231-280 (1)

aa250-299 (1)

aa278-289 (1)

aa383-411 (1)

aa466-515 (1)

pTyr857,pTyr858 (1)

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Publications

No (65)

Sample Type

Adherent Cell Cultures (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

GST (2)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

Baculovirus (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ TNK2 / ACK1 Antibody LS-B12327

(4.0) Rating

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ TNK2 / ACK1 Antibody (aa278-289) LS-B6360

(4.0) Rating

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa278-289) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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TNK2 / ACK1 Antibody (phospho-Tyr284) LS-C34825

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr284) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$984

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TNK2 / ACK1 Antibody (phospho-Tyr518) LS-C97107

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr518) Antibody

Reactivity:

Human

Applications:

DB

Format:

Unconjugated

Price:

400 µl/$393

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TNK2 / ACK1 Antibody (aa934-964) LS-C99164

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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TNK2 / ACK1 Antibody (phospho-Tyr284) LS-C358365

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr284) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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TNK2 / ACK1 Antibody LS-C809625

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TNK2 / ACK1 Antibody (phospho-Tyr518) LS-C291479

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr518) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TNK2 / ACK1 Antibody (220-300 aa) LS-C386793

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (220-300 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TNK2 / ACK1 Antibody (phospho-Tyr284) LS-C826851

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr284) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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TNK2 / ACK1 Antibody (aa10-39) LS-C155932

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa10-39) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

TNK2 / ACK1 Antibody (phospho-Tyr284) LS-C198587

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr284) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TNK2 / ACK1 Antibody (220-300 aa) LS-C381489

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (220-300 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TNK2 / ACK1 Antibody (phospho-Tyr284) LS-C357153

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr284) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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Human TNK2 / ACK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81139

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.4 kDa

Price:

20 µg/$215

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Human TNK2 / ACK1 (Sandwich ELISA) ELISA Kit - LS-F6855

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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TNK2 / ACK1 Antibody LS-C402095

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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TNK2 / ACK1 Antibody LS-C659656

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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TNK2 / ACK1 Antibody (aa934-964) LS-C326779

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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TNK2 / ACK1 Antibody (aa934-964, Biotin) LS-C274816

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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TNK2 / ACK1 Antibody (aa934-964, FITC) LS-C274817

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TNK2 / ACK1 Antibody (aa934-964, APC) LS-C274815

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

TNK2 / ACK1 Antibody (aa934-964, PE) LS-C274820

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

TNK2 / ACK1 Antibody (aa934-964, Azide-free, HRP) LS-C274818

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (aa934-964) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

TNK2 / ACK1 Antibody (phospho-Tyr857,pTyr858) LS-C804441

Antibody:

TNK2 / ACK1 Rabbit anti-Human Polyclonal (pTyr857,pTyr858) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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