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Catalog Number	Size	Price
LS-A7401-50	50 µg (1 mg/ml)	$440

TNIK Antibody - Anti-TNIK antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TNIK Antibody - Anti-TNIK antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TNIK Antibody - Anti-TNIK antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TNIK Antibody - Anti-TNIK antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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PathPlus™ Polyclonal Rabbit anti‑Human TNIK Antibody (Internal, IHC) LS‑A7401

Name: PathPlus™ TNIK Polyclonal Antibody Rabbit anti-Human ICC,IHC | LSBio
Brand: Lifespan BioSciences
SKU: LS-A7401-50
Price: 440.0000 USD
Availability: InStock
Rating: 5 (1 reviews)

Cancer

(5.0) Rating

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Antibody:

TNIK Rabbit anti-Human Polyclonal (Internal) Antibody

Application:

IHC, IHC-P, ICC

Reactivity:

Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken

Format:

Unconjugated, Unmodified

$440

LS-A7401-50

Ready To Ship

Toll Free North America

206-374-1102

For Research Use Only

Specifications Validation Publications Reviews Featured Products Request SDS/MSDS

Overview

Antibody:

TNIK Rabbit anti-Human Polyclonal (Internal) Antibody

Application:

IHC, IHC-P, ICC

Reactivity:

Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken

Format:

Unconjugated, Unmodified

Specifications

Description

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804

Target

Human TNIK

Synonyms

TNIK | ZC2 | KIAA0551

See All TNIK Antibodies

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken (tested or 100% immunogen sequence identity)

Predicted

Xenopus (at least 90% immunogen sequence identity)

Clonality

Polyclonal

Conjugations

Unconjugated

Purification

Immunoaffinity purified

Modifications

Unmodified

Immunogen

Synthetic 18 amino acid peptide from internal region of human TNIK. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Opossum, Chicken, Lizard (100%); Xenopus (94%).

Epitope

Internal

Specificity

Human TNIK. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Applications

IHC
IHC - Paraffin (2 µg/ml)
ICC

Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.

Presentation

PBS, 0.1% Sodium Azide

Storage

Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.

Restrictions

For research use only. Intended for use by laboratory professionals.

Guarantee

This antibody carries the LSBio 100% Guarantee.

LSBio Guarantee

About TNIK

Uniprot: Q9UKE5 NCBI: NM_015028 BAA25477.2

Validation

Breast, Carcinoma

Anti-TNIK antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Prostate, Carcinoma

Pancreas, carcinoma

Anti-TNIK antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.