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TNFSF9 / CD137L
tumor necrosis factor (ligand) superfamily, member 9
TNFSF9 / CD137L is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 9 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF9, 4-1BBL, 4-1BB ligand, 4-1BB-L, CD137L, Homolog of mouse 4-1BB-L, Receptor 4-1BB ligand |
| Target Sequences: | NM_003811 NP_003802.1 P41273 |
Publications (2)
1
Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Jiang D, Yue PS, Drenkard D, Schwarz H. Stem cells (Dayton, Ohio). 2008 26:2372-81.
[PubMed:18566330]
Related Antibodies: LS-C41003.
2
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Ho WT, Pang WL, Chong SM, Castella A, Al-Salam S, Tan TE, Moh MC, Koh LK, Gan SU, Cheng CK, Schwarz H. Cancer research. 2013 73:652-61.
[PubMed:23204227]
Related Antibodies: LS-C41003.
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TNFSF9 / CD137L Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFSF9 / CD137L Mouse anti-Human Monoclonal (Extracellular Domain) (41B436) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µg/$354; 100 µg/$407
Sandwich
96-Well Strip Plate
Human
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
TNFSF9 / CD137L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
TNFSF9 / CD137L Rabbit anti-Human Polyclonal (aa160-209) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Microplate
Human
0.2 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$616
TNFSF9 / CD137L Mouse anti-Human Monoclonal (5F4) Antibody
Human
Flo
Unconjugated
100 µg/$294
TNFSF9 / CD137L Rat anti-Mouse Monoclonal (Extracellular Domain) (203942) Antibody
Mouse
ELISA, Flo, WB
Unconjugated
500 µg/$1,089
TNFSF9 / CD137L Mouse anti-Human Monoclonal (ANC5D6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$446
TNFSF9 / CD137L Mouse anti-Human Monoclonal (Biotin) (ANC5D6) Antibody
Human
ELISA, Flo, Func, WB
Biotin Conjugated
100 µg/$536
TNFSF9 / CD137L Mouse anti-Human Monoclonal (RPE) (ANC5D6) Antibody
Human
ELISA, Flo, WB
RPE Conjugated
120 Tests/$561
TNFSF9 / CD137L Rat anti-Mouse Monoclonal (AT113-2) Antibody
Mouse
Flo, IP
Unconjugated
0.25 mg/$471
TNFSF9 / CD137L Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
TNFSF9 / CD137L Mouse anti-Human Monoclonal (Azide-free) (ANC5D6) Antibody
Human
ELISA, Flo, WB
Unconjugated, Azide-free
100 µg/$446
TNFSF9 / CD137L Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNFSF9 / CD137L Mouse anti-Human Monoclonal (Biotin) (ANC5D6) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
100 µg/$763
TNFSF9 / CD137L Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
TNFSF9 / CD137L Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$271; 100 µl/$412
TNFSF9 / CD137L Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
TNFSF9 / CD137L Mouse anti-Human Monoclonal (aa24-186) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$930; 500 µg/$1,795
TNFSF9 / CD137L Mouse anti-Human Monoclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$896
TNFSF9 / CD137L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
TNFSF9 / CD137L Rabbit anti-Human Polyclonal (aa52-254) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
TNFSF9 / CD137L Rabbit anti-Human Polyclonal (aa31-80) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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