Rat TNFSF4 / OX40L / CD252

Mouse

Rat (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

ATM-2

R. Phycoerythrin. Also available Unconjugated or conjugated with FITC.

Protein G purified

Unmodified

ACI-S1 rat T-cell lymphoma cell line.

Recognizes rat CD252, otherwise known as OX40L or CD134L, a 22kD type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. Clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.

• Flow Cytometry (1:1)
• Applications tested for the base form of this product only

The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA

Reconstitute with distilled water.

Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P23510 NCBI: NM_003326 NP_003317.1