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TNFSF18 / GITRL

tumor necrosis factor (ligand) superfamily, member 18

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Gene Name: tumor necrosis factor (ligand) superfamily, member 18
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF18, AITR ligand, AITRL, GITR ligand, GITRL, HGITRL, TL6
Target Sequences: NM_005092 NP_005083.2 Q9UNG2

☰ Filters
Antibodies (37)
Proteins (19)
ELISA Kits (10)
Custom (2)
Over-Expression Lysate (2)
Primary (37)
Recombinant (17)
Sandwich (8)
TNFSF18 / GITRL (66)
Human (32)
Mouse (16)
Rat (1)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Horse (3)
Monkey (3)
IHC (11)
IHC-P (2)
WB (25)
Flo (10)
ELISA (20)
FLISA (3)
ICC (2)
IHC-IF (1)
IP (2)
Peptide-ELISA (1)
rabbit (28)
mouse (1)
rat (8)
IgG (18)
IgG,k (1)
IgG1 (6)
IgG1,k (1)
IgG2a (1)
IgG2b,l (1)
monoclonal mc (8)
polyclonal pc (26)
recombinant monoclonal rmc (3)
11n77 (1)
B1249M (1)
YGL386 (2)
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96-Well Strip Plate (7)
APC Conjugated (2)
Azide-free (1)
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PE Conjugated (3)
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Preservative Free (1)
Unconjugated (18)
aa114-143 (7)
aa108-157 (4)
GITRL (2)
Extracellular Domain (1)
aa47-173 (1)
aa72-199 (1)
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HEK 293 Cells (7)
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Purified (11)
Low endotoxin level (10)
Biologically active (4)
TNFSF18 / GITRL Antibody - Anti-Human AITRL Western Blot Reduced
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
TNFSF18 / GITRL Antibody - Immunohistochemistry of paraffin-embedded human small intestine using antibody at 1:100 dilution.
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (aa72-199) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
TNFSF18 / GITRL Mouse anti-Human Monoclonal (Extracellular Domain) (PerCP) (11n77) Antibody
Human
Flo
PerCP Conjugated
100 Tests/$930
TNFSF18 / GITRL Antibody - Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 ug/ml.
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
TNFSF18 / GITRL Antibody - IF staining of mouse splenocytes.
Select
TNFSF18 / GITRL Rabbit anti-Mouse Recombinant Monoclonal (GITRL) (YGL386) Antibody
Mouse
ELISA, Flo
Unconjugated
0.2 mg/$540
TNFSF18 / GITRL Antibody - Immunohistochemistry - Anti-TNFSF18/Gitrl Picoband Antibody
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
TNFSF18 / GITRL Rabbit Recombinant Monoclonal Antibody
Flo, ICC, IHC, IHC-IF, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
14.5 kDa (SDS-PAGE)
50 µg/$432; 10 µg/$278; 1 mg/$2,653
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
100 µl/$860
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$860
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, FLISA, IHC, WB
FITC Conjugated
100 µl/$860
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, FLISA, IHC, WB
PE Conjugated
100 µl/$860
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (APC) Antibody
Human
FLISA, IHC, WB
APC Conjugated
100 µl/$860
TNFSF18 / GITRL Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
TNFSF18 / GITRL Rat anti-Mouse Monoclonal (B1249M) Antibody
Mouse
Flo, IP
Unconjugated
100 µg/$649
TNFSF18 / GITRL Antibody - IF staining of mouse splenocytes.
Select
TNFSF18 / GITRL Rat anti-Mouse Recombinant Monoclonal (GITRL) (YGL386) Antibody
Mouse
ELISA, Flo
Unconjugated
0.2 mg/$540
TNFSF18 / GITRL Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using TNFSF18 Polyclonal Antibody at dilution of 1:45(×200)
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TNFSF18 / GITRL Antibody - Western blot analysis of extracts of various cell lines.
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (aa114-143) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (aa114-143) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal (aa114-143) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
TNFSF18 / GITRL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Select
TNFSF18 / GITRL Rat anti-Mouse Monoclonal Antibody
Mouse
Flo
Unconjugated
100 µg/$597
Select
TNFSF18 / GITRL Rat anti-Mouse Monoclonal (aa47-173) Antibody
Mouse
ELISA
Unconjugated
500 µg/$1,089
Viewing 1-25 of 66 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).