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TNFSF11 / RANKL / TRANCE
tumor necrosis factor (ligand) superfamily, member 11
TNFSF11 / RANKL / TRANCE is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 11 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF11, CD254, CD254 antigen, HRANKL2, OPTB2, TRANCE, ODF, OPGL, SOdf, Osteoprotegerin ligand, RANKL |
| Target Sequences: | AF053712 AAC39731.1 O14788 |
Publications (4)
1
Progestin-regulated luminal cell and myoepithelial cell-specific responses in mammary organoid culture. Haslam SZ, Drolet A, Smith K, Tan M, Aupperlee M. Endocrinology. 2008 149:2098-107.
[PubMed:18218689]
[PMC:PMC2329279]
2
Early dissemination seeds metastasis in breast cancer. Hosseini H, Obradovic MM, Hoffmann M, Harper KL, Sosa MS, Werner-Klein M, Nanduri LK, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G,Gužvic M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf AD, Taran FA, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA, Klein CA. Nature. 2016 (WB; Mouse)
[Full Text Article]
[PubMed:27974799]
[PMC:PMC5390864]
3
Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis. Peggy Perrin, Jérome Olagne, Arnaud Delbello, Stanislas Bataille, Laurent Mesnard, Claire Borni, Bruno Moulin, Sophie Caillard. Kidney international reports. 2022 February;7:343-349. [Full Text Article]
[PubMed:35155875]
[PMC:PMC8820998]
Related Antibodies: LS-B1425.
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TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TNFSF11 / RANKL / TRANCE Mouse anti-Mouse Monoclonal (aa1-317) (Azide-free) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated, Azide-free
100 µg/$386
TNFSF11 / RANKL / TRANCE Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$794
TNFSF11 / RANKL / TRANCE Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
500 µg/$326
Sandwich
96-Well Microplate
Mouse
4 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
Sandwich
96-Well Microplate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$636
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Human
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Rat
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
TNFSF11 / RANKL / TRANCE Rabbit anti-Mouse Polyclonal (aa161-177) Antibody
Mouse
WB
Unconjugated
0.1 mg/$386
TNFSF11 / RANKL / TRANCE Goat anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$860
TNFSF11 / RANKL / TRANCE Rat anti-Mouse Monoclonal (IK22/5) Antibody
Mouse
Flo, IF, IHC-Fr, IP, WB
Unconjugated
0.25 mg/$454
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
TNFSF11 / RANKL / TRANCE Mouse anti-Mouse Monoclonal (aa1-317) (12A668) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
TNFSF11 / RANKL / TRANCE Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal (aa41-90) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TNFSF11 / RANKL / TRANCE Rabbit anti-Rabbit Recombinant Monoclonal (IK22-5) Antibody
Rabbit, Mouse
Flo, IHC, Neut
Unconjugated
0.2 mg/$540
TNFSF11 / RANKL / TRANCE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
20 µl/$271; 100 µl/$412
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