Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone OX-40] (IgG2b) to Rat TNFRSF4 / CD134 / OX40
Rat TNFRSF4 / CD134 / OX40
Rat (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [OX-40]
Specificity and Use
Anti-rat CD134 (OX40) monoclonal antibody recognizes an antigen related to NGF on activated T cells that also express CD4. It detects a single chain of 51-55 kD (unreduced) and 47-51 kD (reduced) in immunoprecipitation assay1. OX40/OX40L interaction has.
TNFRSF4 / CD134 / OX40 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis.