Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
IHC - Frozen (1:50)
Flow Cytometry (1:50)
Specificity and Use
TNFRSF1B / TNFR2 antibody was raised against mouse TNF-R2.
Recognizes the extracellular part and the soluble receptor of mouse Tumor Necrosis Factor Receptor Type 2 (TNF-R2). Reactivity of soluble TNF-R2 is not inhibited by high concentrations of mouse TNF-alpha.
Suitable for use in Flow Cytometry, Immunohistochemistry and ELISA. Flow Cytometry: 1:50. Immunohistochemistry (Frozen): 1:50.
PBS, 1% BSA, 0.02% sodium azide
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. FITC conjugates are sensitive to light.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.