Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC - Paraffin, Western blot, ELISA, Neutralization
Rabbit Polyclonal (IgG) to Mouse TNFRSF1B / TNFR2
Western blot, Immunoprecipitation, ELISA
Mouse TNFRSF1B / TNFR2
Mouse (tested or 100% immunogen sequence identity)
Western blot (1:10)
Specificity and Use
Reacts with the extracellular part of the mouse TNF-R II and with the soluble receptor. The reactivity of the antibodies with cell bound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-alpha. Cross-reactivity is minimal with mouse TNF-alpha.
Suitable for ELISA, Western Blot and Immunoprecipitation. Western Blot: 1:10.
PBS, 0.02% sodium azide, 0.1% BSA.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.